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1. (WO2006014345) PROCESS FOR THE SEPARATION OF PACLITAXEL AND CEPHALOMANNIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/014345    International Application No.:    PCT/US2005/023483
Publication Date: 09.02.2006 International Filing Date: 01.07.2005
IPC:
C07D 305/14 (2006.01)
Applicants: IVAX PHARMACEUTICALS s.r.o. [CZ/CZ]; Ostravska 29, Opava 9, 74770 (CZ) (For All Designated States Except US).
BUCHTA, Martin [CZ/CZ]; (CZ) (For US Only).
CVAK, Ladislav [CZ/CZ]; (CZ) (For US Only).
SOBOTIK, Roman [CZ/CZ]; (CZ) (For US Only).
STVERKA, Pavel [CZ/CZ]; (CZ) (For US Only)
Inventors: BUCHTA, Martin; (CZ).
CVAK, Ladislav; (CZ).
SOBOTIK, Roman; (CZ).
STVERKA, Pavel; (CZ)
Agent: FOLEY, Shawn, P.; Lerner, David, Littenberg, Krumholz & Mentlik, LLP, 600 South Avenue West, Westfield, New Jersey 07090-1497 (US)
Priority Data:
60/585,402 02.07.2004 US
Title (EN) PROCESS FOR THE SEPARATION OF PACLITAXEL AND CEPHALOMANNIN
(FR) PROCESSUS DE SÉPARATION DE PACLITAXEL ET DE CÉPHALOMANNINE
Abstract: front page image
(EN)Paclitaxel is separated from a mixture containing cephalomannin by column chromatography on silica gel using a solvent mixture containing methyl isobutyl ketone and a less polar solvent as the mobile phase. The less polar solvent can be a (C5-C8) aliphatic hydrocarbon, a (C6-C8) aromatic hydrocarbon, a (C1-C4) dialkyl ether or their mixtures.
(FR)Le paclitaxel est séparé d'un mélange contenant de la céphalomannine par chromatographie en colonne sur un gel de silicium utilisant un mélange de solvant contenant de la cétone d'isobutyl de méthyle et un solvant moins polaire comme phase mobile. Le solvant moins polaire peut être un hydrocarbure aliphatique (C5-C8), un hydrocarbure aromatique (C6-C8), un éther dialkyle (C1-C4) ou leurs mélanges.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)