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1. (WO2006014168) NICOTINAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/014168    International Application No.:    PCT/US2004/021792
Publication Date: 09.02.2006 International Filing Date: 06.07.2004
IPC:
A61K 31/496 (2006.01), C07D 401/00 (2006.01), A61P 43/00 (2006.01), A61P 3/04 (2006.01), A61P 3/06 (2006.01), A61P 3/10 (2006.01)
Applicants: XENON PHARMACEUTICALS INC. [CA/CA]; 3650 Gilmore Way, Burnaby, British Columbia V5G 4W8 (CA) (For All Designated States Except US).
FU, Jian-Min [CA/CA]; (CA) (For US Only).
KODUMURU, Vishnumurthy [CA/CA]; (CA) (For US Only).
SUN, Shaoyi [CA/CA]; (CA) (For US Only).
WINTHER, Michael, D. [CA/CA]; (CA) (For US Only).
FINE, Richard, M. [US/US]; (US) (For US Only).
HARVEY, Daniel, F. [US/US]; (US) (For US Only).
KLEBANSKY, Boris [US/US]; (US) (For US Only).
GRAY-KELLER, Mark [US/US]; (US) (For US Only).
GSCHWEND, Heinz, W. [US/US]; (US) (For US Only)
Inventors: FU, Jian-Min; (CA).
KODUMURU, Vishnumurthy; (CA).
SUN, Shaoyi; (CA).
WINTHER, Michael, D.; (CA).
FINE, Richard, M.; (US).
HARVEY, Daniel, F.; (US).
KLEBANSKY, Boris; (US).
GRAY-KELLER, Mark; (US).
GSCHWEND, Heinz, W.; (US)
Agent: ROTH, Carol, R.; Seed Intellectual Property Law Group PLLC, Suite 6300, 701 Fifth Avenue, Seattle, WA 98104-7092 (US)
Priority Data:
Title (EN) NICOTINAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS
(FR) DÉRIVÉS DE NICOTINAMIDE ET UTILISATION DE CEUX-CI COMME AGENTS THÉRAPEUTIQUES
Abstract: front page image
(EN)Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where m, n, p, V, R1, R2, R3, R4, R5 and R6 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
(FR)Il est exposé des procédés de traitement d'une maladie ou affection médiée par la SCD (Stéaroyl Coenzyme A désaturase) chez un mammifère, de préférence chez un humain, lesquels procédés comprennent d'administrer à un mammifère qui en a besoin un composé de formule (I) : où m, n, p, V, R1, R2, R3, R4, R5 et R6 sont définis ici. Il est également exposé des compositions pharmaceutiques comprenant les composés de formule (I).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)