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1. (WO2006012616) THERAPEUTIC USE OF ANTI-TF-ANTIGEN ANTIBODY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2006/012616 International Application No.: PCT/US2005/026317
Publication Date: 02.02.2006 International Filing Date: 26.07.2005
IPC:
A61K 31/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
Applicants: RITTENHOUSE-OLSON, Kate[US/US]; US (UsOnly)
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK AT BUFFALO STOR INTELLECTUAL PROPERTY DIVISION[US/US]; UB Technology Incubator, Suite 111 Amherst, NY 14228-2567, US (AllExceptUS)
Inventors: RITTENHOUSE-OLSON, Kate; US
Agent: LOPINSKI, John, D. ; Hodgson Russ LLP One M & T Plaza, Suite 2000 Buffalo, NY 14203-2391, US
Priority Data:
60/591,01126.07.2004US
Title (EN) THERAPEUTIC USE OF ANTI-TF-ANTIGEN ANTIBODY
(FR) UTILISATION THÉRAPEUTIQUE D'ANTICORPS D'ANTIGÈNE ANTI-TF
Abstract:
(EN) The invention is related to administration of monoclonal antibody JAA-Fl 1 to an individual for inhibition of metastasis and/or inhibition of growth of cells which express TF­Ag, or for detection of tumors or metastatic foci which express TF-Ag. For inhibition of metastasis or inhibition of growth of cells expressing TF-Ag, the method comprises administering to the individual a therapeutic amount of mAb JAA-F11, wherein the JAA-F11 mAb inhibits the metastasis and/or growth of the TF-Ag expressing cancer cells. For detection of tumors or metastatic foci, mAb JAA-F11 is conjugated to a detectable label and administered to the individual. Detection of the label identifies metatstatic foci or tumors which comprise cancer cells expressing TF-Ag.
(FR) La présente invention a trait à l'administration d'un anticorps monoclonal JAA-F11 à un sujet pour l'inhibition de métastase et/ou l'inhibition de croissance de cellules d'expression de TF-Ag, ou pour la détection de tumeurs ou de foyers métastatiques d'expression de TF-Ag. Pour l'inhibition de métastase ou l'inhibition de croissance de cellules d'expression de TF-Ag, le procédé comprend l'administration au sujet d'une quantité thérapeutique d'anticorps monoclonal JAA-F11, selon lequel l'anticorps JAA-F11 assure l'inhibition de métastase et/ou de croissance de cellules cancéreuses d'expression de TF-Ag. Pour la détection de tumeurs ou de foyers métastatiques, l'anticorps monoclonal JAA-F11 est conjugué à un traceur détectable et administré au sujet. La détection du traceur identifie les foyers métastatiques ou tumeurs comportant des cellules cancéreuses d'expression de TF-Ag.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)