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1. (WO2006012374) SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/012374    International Application No.:    PCT/US2005/025800
Publication Date: 02.02.2006 International Filing Date: 20.07.2005
IPC:
C07D 401/12 (2006.01), C07D 413/14 (2006.01), C07D 401/14 (2006.01), C07D 405/12 (2006.01), C07D 405/14 (2006.01), C07D 217/02 (2006.01), C07D 403/12 (2006.01), C07D 417/14 (2006.01), C07D 471/04 (2006.01), A61K 31/443 (2006.01), A61K 31/4427 (2006.01), A61K 31/4439 (2006.01), A61K 31/444 (2006.01), A61K 31/4725 (2006.01), A61P 35/00 (2006.01)
Applicants: AMGEN INC. [US/US]; M/S 28-2-C, One Amgen Center Drive, Thousand Oaks, CA 91320-1799 (US) (For All Designated States Except US).
YUAN, Chester Chenguang [US/US]; (US) (For US Only).
YANG, Kevin [US/US]; (US) (For US Only).
VANDERPLAS, Simon [NL/CA]; (CA) (For US Only).
RIAHI, Babak [US/US]; (US) (For US Only).
POTASHMAN, Michele [US/US]; (US) (For US Only).
PATEL, Vinod F. [US/US]; (US) (For US Only).
NOMAK, Rana [TR/TR]; (TR) (For US Only).
LI, Aiwen [CN/US]; (US) (For US Only).
HUANG, Qi [CN/US]; (US) (For US Only).
HARMANGE, Jean-Christophe [FR/US]; (US) (For US Only).
ASKEW, JR., Benny C. [US/US]; (US) (For US Only)
Inventors: YUAN, Chester Chenguang; (US).
YANG, Kevin; (US).
VANDERPLAS, Simon; (CA).
RIAHI, Babak; (US).
POTASHMAN, Michele; (US).
PATEL, Vinod F.; (US).
NOMAK, Rana; (TR).
LI, Aiwen; (US).
HUANG, Qi; (US).
HARMANGE, Jean-Christophe; (US).
ASKEW, JR., Benny C.; (US)
Priority Data:
60/590,544 22.07.2004 US
11/185,556 19.07.2005 US
Title (EN) SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE
(FR) DÉRIVÉS AMINÉS À SUBSTITUTION ARYLE ET PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)The present invention provides classes of compounds, including-their pharmaceutically acceptable derivatives, useful for treating angiogenesis and related diseases such as cancer. Formula I and II wherein R is a 9- or 10-membered heterocyclyl ring selected from 7-isoquinolinyl,..2-methyl-3-oxo-2,3-dihydroindazol-6-yl, [1,6]-naphthydrin-3-yl, [1,7]-naphthydrin-2-yl, 1-oxo-2,3-dihydrobenzofuran-4-yl, 3-oxo-2,3-dihydrobenzofuran-5-yl, dihydro-benzodioxinyl, 6-quinazolinyl, 2-amino-6-quinazolinyl, 4-methylamino-6-quinazolinyl, 2,4-diamino-6 quinazolinyl, 3-oxo-3,4-dihydro-1,4-benzoxazin-6-yl, 2,2-difluoro-l;3-benzodioxol-5-yl and 2,2,3,3 tetrafluoro-2,3-dihydro-l,4-benzodioxin-6-yl, each of which is optionally substituted with one or more substituents selected from halo, haloakyl, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, N-dimethylamino-C1-6-alkyl, N-dimethylamino-C1-6-alkoxy, amino, alkyl-carbonylamino, morpholino-sulfonyl, amino-sulfonyl, oxazolyl, pyrrolyl,4 morpholinyl, carboxyl, cyano, and acetyl; wherein R1 in formula I is selected from unsubstituted or substituted phenyl, 5-6 membered heteroaryl, 9-10 membered bicyclic heterocyclyl and 11-14 membered tricyclic heterocyclyl, and R1 in formula II is selected from specific bicyclic heterocycles.
(FR)La présente invention concerne des classes de composés, incluant leurs dérivés pharmaceutiquement acceptables, utiles pour traiter l'angiogenèse et les maladies associées telles que le cancer. Les formules I et II dans lesquelles R est un hétérocycle à 9 ou 10 éléments choisi à partir de 7-isoquinolinyle, 2-méthyl-3-oxo-2,3-dihydroindazol-6-yle, [1,6]-naphthydrin-3-yle, [1,7]-naphthydrin-2-yle, 1-oxo-2,3-dihydrobenzofuran-4-yle, 3-oxo-2,3-dihydrobenzofuran-5-yle, dihydro-benzodioxinyle, 6-quinazolinyle, 2-amino-6-quinazolinyle, 4-méthylamino-6-quinazolinyle, 2,4-diamino-6 quinazolinyle, 3-oxo-3,4-dihydro-1,4-benzoxazin-6-yle, 2,2-difluoro-l,3-benzodioxol-5-yle et 2,2,3,3 tétrafluoro-2,3-dihydro-l,4-benzodioxin-6-yle, chacun d'eux est facultativement substitué avec un ou plusieurs substituants choisis parmi halo, haloalkyle, C1-6 alkyle, C2-8 alcényle, C2-8 alkynyle, N-diméthylamino-C1-6-alkyle, N-diméthylamino-C1-6-alkoxy, amino, alkyl-carbonylamino, morpholino-sulfonyle, amino-sulfonyle, oxazolyle, pyrrolyle,4 morpholinyle, carboxyle, cyano, et acétyle; où R' dans la formule I est choisi parmi un phényle substitué ou non substitué, un hétéroaryle à 5-6 éléments, un hétérocycle bicyclique à 9-10 éléments et un hétérocycle tricyclique à 11-14 éléments, et R' dans la formule II est choisi à partir d'hétérocycles bicycliques spécifiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)