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Machine translation
1. (WO2006012308) BISARYLUREA DERIVATIVES USEFUL FOR INHIBITING CHK1
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/012308    International Application No.:    PCT/US2005/022515
Publication Date: 02.02.2006 International Filing Date: 24.06.2005
IPC:
C07D 401/12 (2006.01), C07D 241/20 (2006.01), C07D 405/14 (2006.01), A61K 31/4965 (2006.01), A61P 35/00 (2006.01)
Applicants: ICOS CORPORATION [US/US]; 22021 20th Avenue S.E., Bothell, WA 98021 (US) (For All Designated States Except US).
BURGESS, Laurence, Edward [US/US]; (US) (For US Only).
COOK, Adam, Wade [US/US]; (US) (For US Only).
FISCHER, Kimba, L. [US/US]; (US) (For US Only).
GAUDINO, John, Joseph [US/US]; (US) (For US Only).
SCHLACHTER, Stephen, T. [US/US]; (US) (For US Only)
Inventors: BURGESS, Laurence, Edward; (US).
COOK, Adam, Wade; (US).
FISCHER, Kimba, L.; (US).
GAUDINO, John, Joseph; (US).
SCHLACHTER, Stephen, T.; (US)
Agent: NAPOLI, James, J.; Marshall, Gerstein & Borun LLP, 233 S. Wacker Drive, Suite 6300, Sears Tower, Chicago, IL 60606-6357 (US)
Priority Data:
60/583,080 25.06.2004 US
Title (EN) BISARYLUREA DERIVATIVES USEFUL FOR INHIBITING CHK1
(FR) DÉRIVÉS DE BISARYLURÉE UTILES POUR INHIBER CHK1
Abstract: front page image
(EN)Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed. Formula (I).
(FR)L’invention décrit des composés d'urée à substitution aryle et hétéroaryle utiles dans le traitement de maladies et de conditions liées à l’endommagement ou aux lésions de l'ADN au cours de la réplication de l'ADN. Des procédés de fabrication des composés, et leur utilisation comme agents thérapeutiques, par exemple, dans le traitement du cancer et autres maladies caractérisées par des défauts de réplication de l'ADN, une ségrégation des chromosomes, ou une division cellulaire sont également décrits. Formule (I).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)