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1. (WO2006012173) AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/012173    International Application No.:    PCT/US2005/022170
Publication Date: 02.02.2006 International Filing Date: 23.06.2005
IPC:
C07D 401/02 (2006.01), C07D 405/00 (2006.01), C07D 211/96 (2006.01), A61K 31/438 (2006.01), A61K 31/4439 (2006.01), A61K 31/444 (2006.01)
Applicants: INCYTE CORPORATION [US/US]; Experimental Station, Building 336, Route 141 and Henry Clay Road, Wilmington, DE 19880 (US) (For All Designated States Except US).
YAO, Wenqing [US/US]; (US) (For US Only).
LI, Yanlong [US/US]; (US) (For US Only).
XU, Meizhong [CN/US]; (US) (For US Only).
ZHUO, Jincong [CN/US]; (US) (For US Only).
ZHANG, Colin [CN/US]; (US) (For US Only).
METCALF, Brian [US/US]; (US) (For US Only)
Inventors: YAO, Wenqing; (US).
LI, Yanlong; (US).
XU, Meizhong; (US).
ZHUO, Jincong; (US).
ZHANG, Colin; (US).
METCALF, Brian; (US)
Agent: GODDARD, Christine, A, Ph., D.; Fish and Richardson P.C., P.O. Box 1022, Minneapolis, MN 55440-1022 (US)
Priority Data:
60/582,478 24.06.2004 US
Title (EN) AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS
(FR) COMPOSES AMIDO ET UTILISATION DE CEUX-CI COMME AGENTS PHARMACEUTIQUES
Abstract: front page image
(EN)The present invention relates to inhibitors of 11-&bgr; hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-&bgr; hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
(FR)L'invention concerne des inhibiteurs du type 1 de la 11-ß hydroxyl stéroïde déshydrogénase, des antagonistes du récepteur minéralocorticoïde (MR) et des compositions pharmaceutiques de ceux-ci. Les composés selon l'invention peuvent être utiles dans le traitement de diverses maladies associées à l'expression ou à l'activité du type 1 de la 11-ß hydroxyl stéroïde déshydrogénase et/ou des maladies associées à un excès d'aldostérone.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)