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1. (WO2006011588) MEDICINAL COMPOSITION CONTAINING DIABETES REMEDY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2006/011588 International Application No.: PCT/JP2005/013912
Publication Date: 02.02.2006 International Filing Date: 29.07.2005
IPC:
A61K 31/7056 (2006.01) ,A61K 31/198 (2006.01) ,A61K 31/427 (2006.01) ,A61K 31/4439 (2006.01) ,A61K 38/28 (2006.01) ,A61K 45/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7052
having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
7056
containing five-membered rings with nitrogen as a ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
197
the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198
Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
427
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4439
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
28
Insulins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
Applicants: IZUMI, Masanori; null (UsOnly)
OKUNO, Akira; null (UsOnly)
MATSUMURA, Keiko; null (UsOnly)
SANKYO COMPANY, LIMITED[JP/JP]; 5-1, Nihonbashi Honcho 3-chome Chuo-ku, Tokyo 1038426, JP (AllExceptUS)
Inventors: IZUMI, Masanori; null
OKUNO, Akira; null
MATSUMURA, Keiko; null
Agent: YAGUCHI, Toshiaki; c/o SANKYO COMPANY, LIMITED 2-58, Hiromachi 1-chome Shinagawa-ku, Tokyo 1408710, JP
Priority Data:
2004-22241929.07.2004JP
Title (EN) MEDICINAL COMPOSITION CONTAINING DIABETES REMEDY
(FR) COMPOSITION MÉDICINALE CONTENANT UN REMÈDE AU DIABÈTE
(JA) 糖尿病治療薬を含有する医薬組成物
Abstract:
(EN) A medicinal composition effective in the prevention and treatment of diabetes. The medicinal composition comprises a combination of: an &agr;-amylase inhibitor selected between a compound represented by the following general formula (I): (wherein A represents a cyclic group, etc.; R1 and R2 each represents alkyl, hydroxylmethyl, etc.; and n is 1 or 2) and a pharmacologically acceptable salt or ester of the compound; and at least one drug selected among an insulin sensitivity enhancer, insulin secretion accelerator, biguanide agent, insulin preparation, and DPP-IV inhibitor.
(FR) Cette composition médicale est efficace dans la prévention et le traitement du diabète. La composition médicale comprend une combinaison de : un inhibiteur d'&agr;-amylase choisi parmi un composé représenté par la formule générale suivante (I) : (où A représente un groupe cyclique, etc. ; R1 et R2 représentent chacun de l'alkyle, de l'hydroxylméthyle, etc.; n vaut 1 ou 2) et un sel pharmacologiquement acceptable ou un ester du composé ; au moins un médicament choisi parmi un activateur de sensibilité à l'insuline, un accélérateur de la sécrétion d'insuline, un agent biguanide, une préparation d'insuline et un inhibiteur de DPP-IV.
(JA)  糖尿病の予防及び治療に有効な医薬組成物を提供する。  下記一般式(I)  [Aは環状基等、R1及びRはアルキル基、ヒドロキシメチル基等、nは1又は2を示す。] の化合物又はその薬理上許容される塩若しくはエステルから選ばれるα‐アミラーゼ阻害剤と、インスリン感受性増強剤、インスリン分泌促進剤、ビグアナイド剤、インスリン製剤及びDPP-IV阻害剤から選ばれる少なくとも1種の薬剤とを組み合わせてなる医薬組成物。
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)