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1. (WO2006011136) NOVEL NAPHTHOQUINONE DERIVATIVES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2006/011136 International Application No.: PCT/IL2005/000783
Publication Date: 02.02.2006 International Filing Date: 21.07.2005
IPC:
A61K 31/135 (2006.01)
Applicants: GRANOT, Yossi[IL/IL]; IL (UsOnly)
BITTNER, Shmuel[IL/IL]; IL (UsOnly)
BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY[IL/IL]; P.O.B. 653 84105 Beer Sheva, IL (AllExceptUS)
Inventors: GRANOT, Yossi; IL
BITTNER, Shmuel; IL
Agent: LUZZATTO, Kfir ; P.O. Box 5352 84152 Beer Sheva, IL
Priority Data:
16321626.07.2004IL
Title (EN) NOVEL NAPHTHOQUINONE DERIVATIVES AND USES THEREOF
(FR) NOUVEAUX DERIVES DE NAPHTOQUINONE ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES CARDIOVASCULAIRES ET DE MALIGNITES
Abstract:
(EN) The invention provides naphthoquinone derivatives that modulate the activity of protein kinases, and it relates to the use of the derivatives in pharmaceutical compositions for treating cardiovascular disorders and malignancies. The invention particularly provides medicaments for treating disorders associated with MAPKs signaling, ERKs signaling, p38 signaling, and JNKs signaling.
(FR) L'invention concerne des dérivés de naphtoquinone qui modulent l'activité des protéines kinases, et leur utilisation dans des compositions pharmaceutiques destinées au traitement de troubles cardiovasculaires et de malignités. L'invention concerne plus particulièrement des médicaments destinés au traitement de troubles associés à la signalisation de la protéine kinase activée par mitogène (MAPK), à la signalisation de kinase à régulation extracellulaire (ERK), à la signalisation p38 et à la signalisation de c-JunN-terminal kinase (JNK).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)