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Machine translation
1. (WO2006011052) METHOD FOR THE RACEMIZATION OF 2-TRIFLUORO-2H-CHROMENE-3-CARBOXYLIC ACIDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/011052    International Application No.:    PCT/IB2005/002232
Publication Date: 02.02.2006 International Filing Date: 11.07.2005
Chapter 2 Demand Filed:    16.09.2005    
IPC:
C07D 311/58 (2006.01)
Applicants: PHARMACIA & UPJOHN COMPANY LLC [US/US]; 301 Henrietta Street, Kalamazoo, MI 49001 (US) (For All Designated States Except US).
NG, John, Sauhoi [US/US]; (US) (For US Only).
WIECZOREK, Joseph, J. [US/US]; (US) (For US Only)
Inventors: NG, John, Sauhoi; (US).
WIECZOREK, Joseph, J.; (US)
Agent: FULLER, Grover, F., Jr.; c/o Lawrence, Jackie, Pfizer Inc. MS8260-1615, Eastern Point Road, Groton, CT 06340 (US)
Priority Data:
60/590,515 23.07.2004 US
Title (EN) METHOD FOR THE RACEMIZATION OF 2-TRIFLUORO-2H-CHROMENE-3-CARBOXYLIC ACIDS
(FR) PROCEDE DE RACEMISATION D'ACIDES CARBOXYLIQUES 2-TRIFLUORO-2H-CHROMENE-3
Abstract: front page image
(EN)This invention relates to a method for racemizing enantiomers of a substituted 2-trifluoromethyl-2H-chromene-3-carboxylic acid or ester, a substituted 2-tri fluoromethyl-1,2-dihydro-quinoline-3-carboxylic acid or ester, a substituted 2-tril uoromethyl-2H-thiochromene-3-carboxylic acid or ester, or a pharmaceutically acceptable salt of the acids or esters, using secondary amines, and optionally hydroxides, alkoxides, or sulfites at reaction mixture temperatures of from about 30 °C (i.e., above room temperature) to less than 300°C.
(FR)L'invention concerne un procédé de racémisation des énantiomères d'un acide carboxylique ou ester 2-trifluorométhyl-2H-chromène-3 substitué, d'un acide carboxylique ou ester 2-trifluorométhyl-1,2-dihydro-quinoline-3 substitué, d'un acide carboxylique ou ester 2-trifluorométhyl-2H-thiochromène-3 substitué, ou d'un sel acceptable d'un point de vue pharmaceutique desdits acides ou esters, à l'aide d'amines secondaires et, éventuellement, d'hydroxydes, d'alkoxydes ou de sulfites, à des températures de mélange de réaction d'environ 30 °C (c'est-à-dire supérieures à la température ambiante) à moins de 300 °C.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)