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1. (WO2006010637) PYRIDINYLAMINES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2006/010637 International Application No.: PCT/EP2005/008321
Publication Date: 02.02.2006 International Filing Date: 01.08.2005
IPC:
C07D 213/74 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
72
Nitrogen atoms
74
Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Applicants:
EICKHOFF, Jan, Eike [DE/DE]; DE (UsOnly)
HAFENBRADL, Doris [DE/DE]; DE (UsOnly)
SCHWAB, Wilfried [DE/DE]; DE (UsOnly)
COTTON, Matthew [US/DE]; DE (UsOnly)
KLEBL, Bert, Matthias [DE/DE]; DE (UsOnly)
ZECH, Birgit [DE/DE]; DE (UsOnly)
MÜLLER, Stefan [DE/DE]; DE (UsOnly)
HARRIS, John [GB/GB]; GB (UsOnly)
SAVIC, Vladimir [YU/GB]; GB (UsOnly)
MACRITCHIE, Jackie [GB/GB]; GB (UsOnly)
SHERBORNE, Brad [GB/GB]; GB (UsOnly)
LE, Joelle [GB/GB]; GB (UsOnly)
GPC BIOTECH AG [DE/DE]; Fraunhoferstr. 20 82152 Martinsried, DE (AllExceptUS)
Inventors:
EICKHOFF, Jan, Eike; DE
HAFENBRADL, Doris; DE
SCHWAB, Wilfried; DE
COTTON, Matthew; DE
KLEBL, Bert, Matthias; DE
ZECH, Birgit; DE
MÜLLER, Stefan; DE
HARRIS, John; GB
SAVIC, Vladimir; GB
MACRITCHIE, Jackie; GB
SHERBORNE, Brad; GB
LE, Joelle; GB
Agent:
DÖRRIES, FRANK-MOLNIA & POHLMAN; Triftstrasse 13 80538 Munich, DE
Priority Data:
04018131.530.07.2004EP
60/599,30706.08.2004US
Title (EN) PYRIDINYLAMINES
(FR) PYRIDINYLAMINES
Abstract:
(EN) Described are pyridinylamines and pharmaceutically acceptable salts thereof, the use of these pyridinylamines for the prophylaxis and/or treatment of various diseases such as infectious diseases, including opportunistic infections, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as pharmaceutical compositions containing at least one pyridinylamine and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the pyridinylamines are disclosed.
(FR) La présente invention a trait à des pyridinylamines et leurs sels pharmaceutiquement acceptables, l'utilisation de ces pyridinylamines pour la prophylaxie et/ou le traitement de diverses maladies telles que des maladies infectieuses, comprenant des infections opportunistes, des maladies à prion, des maladies immunologiques, des maladies auto-immunes, des troubles bipolaires et cliniques, des maladies cardio-vasculaires, des maladies de prolifération cellulaire, le diabète, l'inflammation, les rejets de transplantation, le dysfonctionnement érectile, les maladies neurodégénératives et l'accident vasculaire cérébral, ainsi qu'à des compositions pharmaceutiques contenant au moins une pyridinylamine et/ou des sels acceptable de celle-ci. L'invention a également trait à des procédés de réaction pour la synthèse des pyridinylamines.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)