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1. WO2006010557 - D-GLUCOPYRANOSYL PHENYL-SUBSTITUTED CYCLENE, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE, AND METHOD FOR THE PRODUCTION THEREOF

Publication Number WO/2006/010557
Publication Date 02.02.2006
International Application No. PCT/EP2005/007956
International Filing Date 21.07.2005
IPC
C07D 309/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
309Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
02having no double bonds between ring members or between ring members and non-ring members
08with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
10Oxygen atoms
12only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
A61K 31/351 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
351not condensed with another ring
A61P 3/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
CPC
A61P 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
06Antihyperlipidemics
A61P 3/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
Applicants
  • BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE]/[DE] (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW)
  • BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG [DE]/[DE] (DE)
  • ECKHARDT, Matthias [DE]/[DE] (UsOnly)
  • HIMMELSBACH, Frank [DE]/[DE] (UsOnly)
  • EICKELMANN, Peter [DE]/[DE] (UsOnly)
  • THOMAS, Leo [DE]/[DE] (UsOnly)
  • BARSOUMIAN, Edward Leon [US]/[US] (UsOnly)
Inventors
  • ECKHARDT, Matthias
  • HIMMELSBACH, Frank
  • EICKELMANN, Peter
  • THOMAS, Leo
  • BARSOUMIAN, Edward Leon
Common Representative
  • BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Priority Data
10 2004 036 314.527.07.2004DE
10 2004 046 012.421.09.2004DE
Publication Language German (de)
Filing Language German (DE)
Designated States
Title
(DE) D-GLUCOPYRANOSYL-PHENYL-SUBSTITUIERTE CYCLEN, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG
(EN) D-GLUCOPYRANOSYL PHENYL-SUBSTITUTED CYCLENE, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE, AND METHOD FOR THE PRODUCTION THEREOF
(FR) CYCLENES SUBSTITUES PAR D-GLUCOPYRANOSYLE-PHENYLE, MEDICAMENTS CONTENANT LESDITS COMPOSES, LEUR UTILISATION ET PROCEDE DE PRODUCTION CORRESPONDANT
Abstract
(DE) D-Glucopyranosyl-phenyl-substituierte Cyclen der allgemeinen Formel (I), wobei die Reste R1 bis R6, Z, Cy sowie R7a, R7b, R7c, R7d wie in Anspruch 1 definiert sind, besitzen eine inhibierende Wirkung auf den natriumabhängigen Glucose-Cotransporter SGLT. Die vorliegende Erfindung betrifft auch Arzneimittel zur Behandlung von Stoffwechselerkrankungen.
(EN) The invention relates to D-glucopyranosyl phenyl-substituted cyclene of general formula (I), in which: radicals R1 to R6, Z, Cy as well as R7a, R7b, R7c, R7d are defined as in Claim 1. The inventive compounds have an inhibitory effect upon the sodium-dependent glucose co-transporter SGLT. The invention also relates to medicaments for treating metabolic diseases.
(FR) L'invention concerne des cyclènes substitués par D-glucopyranosyle-phényle de formule (I) dans laquelle les restes R1 à R6, Z, Cy, ainsi que R7, R7, R7, R7 sont définis comme dans la revendication 1. Lesdits composés présentent une action inhibitrice sur les glucose-cotransporteurs sodium-dépendants SGLT. L'invention concerne également des médicaments utilisés pour traiter des maladies métaboliques.
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