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1. (WO2006010494) DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH METHIONINE AMINOPEPTIDASE 1 (METAPI)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/010494    International Application No.:    PCT/EP2005/007703
Publication Date: 02.02.2006 International Filing Date: 15.07.2005
IPC:
G01N 33/574 (2006.01), C12Q 1/37 (2006.01)
Applicants: BAYER HEALTHCARE AG [DE/DE]; 51368 Leverkusen (DE) (For All Designated States Except US).
GOLZ, Stefan [DE/DE]; (DE) (For US Only).
BRÜGGEMEIER, Ulf [DE/DE]; (DE) (For US Only).
GEERTS, Andreas [DE/DE]; (DE) (For US Only)
Inventors: GOLZ, Stefan; (DE).
BRÜGGEMEIER, Ulf; (DE).
GEERTS, Andreas; (DE)
Common
Representative:
BAYER HEALTHCARE AG; Law and Patents, Patents and Licensing, 51368 Leverkusen (DE)
Priority Data:
04017832.9 28.07.2004 EP
Title (EN) DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH METHIONINE AMINOPEPTIDASE 1 (METAPI)
(FR) MOYENS DE DIAGNOSTIC ET DE TRAITEMENT POUR DES MALADIES ASSOCIEES A LA METHIONINE AMINOPEPTIDASE 1 (METAP1)
Abstract: front page image
(EN)The invention provides a human MetAP1 which is associated with the cardiovascular diseases, infections, respiratory diseases, gastroenterological diseases, cancer, hematological diseases, muscle skeleton diseases, metabolic diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, infections, respiratory diseases, gastroenterological diseases, cancer, hematological diseases, muscle skeleton diseases, metabolic diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of MetAP1 as well as pharmaceutical compositions comprising such compounds.
(FR)L'invention concerne une MetAP1 humaine qui est associée à des maladies cardiovasculaires, des infections, des maladies respiratoires, des maladies gastroentérologiques, au cancer, à des maladies hématologiques, des maladies musculosquelettiques, des maladies métaboliques, des maladies neurologiques, et à des maladies urologiques. Cette invention concerne également des analyses pour identifier des composés servant à traiter ou prévenir des maladies cardiovasculaires, des infections, des maladies respiratoires, des maladies gastroentérologiques, le cancer, des maladies hématologiques, des maladies musculosquelettiques, des maladies métaboliques, des maladies neurologiques, et des maladies urologiques. La présente invention se rapporte en outre à des composés qui se lient à MetAP1 et/ou activent ou inhibent l'activité de cette enzyme, ainsi qu'à des compositions pharmaceutiques contenant ces composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)