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Machine translation
1. (WO2005124352) METHOD FOR DETERMINING AGGRECANASE ACTIVITIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/124352    International Application No.:    PCT/DE2005/001114
Publication Date: 29.12.2005 International Filing Date: 17.06.2005
IPC:
G01N 33/573 (2006.01)
Applicants: INVITEK GESELLSCHAFT FÜR BIOTECHNIK & BIODESIGN MBH [DE/DE]; Robert-Rössle-Strasse 10, 13125 Berlin (DE) (For All Designated States Except US).
WILL, Horst [DE/DE]; (DE) (For US Only).
DETTLOFF, Matthias [DE/DE]; (DE) (For US Only).
STROH, Torsten [DE/DE]; (DE) (For US Only).
OSWALD, Monique [DE/DE]; (DE) (For US Only).
BENDZKO, Peter [DE/DE]; (DE) (For US Only)
Inventors: WILL, Horst; (DE).
DETTLOFF, Matthias; (DE).
STROH, Torsten; (DE).
OSWALD, Monique; (DE).
BENDZKO, Peter; (DE)
Agent: BAUMBACH, F.; Robert-Rössle-Strasse 10, 13125 Berlin (DE)
Priority Data:
10 2004 029 470.4 18.06.2004 DE
Title (DE) VERFAHREN ZUR BESTIMMUNG VON AGGREKANASE-AKTIVITÄTEN
(EN) METHOD FOR DETERMINING AGGRECANASE ACTIVITIES
(FR) PROCEDE DE DETERMINATION DES ACTIVITES DE L'AGGRECANASE
Abstract: front page image
(DE)Die Erfindung betrifft die Verwendung rekombinanter und chemisch modifizierter Aggrekanfragmente als Substrate zur Bestimmung von Aggrekanase-Aktivitäten. Sie betrifft weiterhin die Gewinnung von Antikörpern gegen Spaltprodukte der Aggrekanfragmente sowie einem Assay zur Messung von Aggrekanase-Aktivität. Anwendungsgebiete der Erfindung sind die Medizin und die pharmazeutische Industrie.
(EN)The invention relates to the use of recombinant and chemically modified aggrecan fragments as substrates for the determination of aggrecanase activities. The invention also relates to the production of antibodies against cleavage products of aggrecan fragments and to an assay for the measurement of aggrecanase activity. Fields of application of the invention: medicine and the pharmaceutical industry.
(FR)Utilisation de fragments d'aggrecan recombinés et chimiquement modifiés en tant que substrats pour la détermination des activités de l'aggrécanase. La présente invention concerne en outre la production d'anticorps contre des produits de clivage des fragments d'aggrecan ainsi qu'une analyse permettant de mesurer l'activité de l'aggrécanase. Les domaines d'application de la présente invention sont la médecine et l'industrie pharmaceutique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: German (DE)
Filing Language: German (DE)