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1. (WO2005123955) METHODS AND COMPOSITIONS FOR MODIFYING GENE REGULATION AND DNA DAMAGE IN AGEING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/123955    International Application No.:    PCT/US2005/020159
Publication Date: 29.12.2005 International Filing Date: 09.06.2005
Chapter 2 Demand Filed:    28.11.2005    
IPC:
C12Q 1/68 (2006.01)
Applicants: CHILDREN'S MEDICAL CENTER CORPORATION [US/US]; 300 Longwood Avenue, Boston, MA 02115 (US) (For All Designated States Except US).
YANKNER, Bruce [US/US]; (US) (For US Only).
LU, Tao [CN/US]; (US) (For US Only)
Inventors: YANKNER, Bruce; (US).
LU, Tao; (US)
Agent: ENGELLENNER, Thomas, J.; Nutter McClennen & Fish LLP, World Trade Center West, 155 Seaport Boulevard, Boston, MA 02210-2604 (US)
Priority Data:
60/582,329 09.06.2004 US
Title (EN) METHODS AND COMPOSITIONS FOR MODIFYING GENE REGULATION AND DNA DAMAGE IN AGEING
(FR) PROCEDES ET COMPOSITIONS DE MODIFICATION DE LA REGULATION DU GENE ET DU DOMMAGE A L'ADN EN RAISON DU VIEILLISSEMENT
Abstract: front page image
(EN)The invention relates to gene regulation in ageing, and age-related cognitive decline. The invention, in particular relates to methods for screening a subject for a propensity to develop diseases associated with oxidative stress, and for age-related conditions, by examining the up-regulation and/or down-regulation of at least one gene associated within the central nervous system.
(FR)L'invention concerne la régulation génique avec le vieillissement, ainsi que les troubles de connaissance liés à l'âge. Cette invention porte notamment sur des procédés de criblage d'un sujet présentant une tendance à développer des maladies associées à un stress oxydatif, et des conditions liées à l'âge, par examen de la régulation positive et/ou de la régulation négative d'au moins un gène associé au système nerveux central.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)