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Pub. No.:    WO/2005/123745    International Application No.:    PCT/JP2005/011325
Publication Date: 29.12.2005 International Filing Date: 21.06.2005
C07D 495/04 (2006.01), A61K 31/4365 (2006.01), A61K 31/4545 (2006.01), A61K 31/4743 (2006.01), A61K 31/496 (2006.01), A61K 31/4985 (2006.01), A61K 31/5377 (2006.01), A61K 31/55 (2006.01), A61K 31/551 (2006.01), A61P 19/02 (2006.01), A61P 29/00 (2006.01), A61P 37/00 (2006.01), A61P 43/00 (2006.01), C07D 495/14 (2006.01), C07D 519/00 (2006.01)
Applicants: ASTELLAS PHARMA INC. [JP/JP]; 3-11, Nihonbashi-honcho 2-chome, Chuo-ku, Tokyo 1038411 (JP) (For All Designated States Except US).
KOTOBUKI PHARMACEUTICAL CO., LTD. [JP/JP]; 6351, Oaza-Sakaki, Sakaki-machi, Hanishina-gun, Nagano 3890697 (JP) (For All Designated States Except US).
OKAMOTO, Yoshinori [JP/JP]; (JP) (For US Only).
HATTORI, Kazuyuki [JP/JP]; (JP) (For US Only).
KUBOTA, Hirokazu [JP/JP]; (JP) (For US Only).
SATO, Ippei [JP/JP]; (JP) (For US Only).
KANAYAMA, Takatoshi [JP/JP]; (JP) (For US Only).
YOKOYAMA, Kazuhiro [JP/JP]; (JP) (For US Only).
TERAI, Yoshiya [JP/JP]; (JP) (For US Only).
TAKEUCHI, Masahiro [JP/JP]; (JP) (For US Only)
Inventors: OKAMOTO, Yoshinori; (JP).
HATTORI, Kazuyuki; (JP).
KUBOTA, Hirokazu; (JP).
SATO, Ippei; (JP).
KANAYAMA, Takatoshi; (JP).
YOKOYAMA, Kazuhiro; (JP).
TERAI, Yoshiya; (JP).
TAKEUCHI, Masahiro; (JP)
Agent: WATANABE, Kazuhira; 3rd Fl., No.8 Kikuboshi Tower Bldg. 20-18, Asakusabashi 3-chome Taito-ku, Tokyo 1110053 (JP)
Priority Data:
2004-183073 21.06.2004 JP
(JA) 三環系化合物
Abstract: front page image
(EN)Tricyclic compounds characterized by bearing a pyridine ring substituted with either a nitrogenous saturated heterocyclic group or a substituted amino group and a thiophene ring having carboxamido and amino thereon, which compounds have excellent anti-inflammatory effects based on the inhibition of IKK2; and therapeutic or preventive drugs for inflammatory diseases, autoimmune diseases, and so on, containing the compounds.
(FR)Composés tricycliques caractérisés par le fait qu’ils portent un noyau pyridinique substitué avec soit un groupe hétérocyclique saturé azoté, soit un groupe aminé substitué et un noyau thiophénique comportant un groupe carboxamide et un groupe amine, lesquels composés ont des effets anti-inflammatoires excellents basés sur l’inhibition de IKK2 ; et médicaments thérapeutiques ou préventifs pour les maladies inflammatoires, pour les maladies auto-immunes, et ainsi de suite, contenant les composés.
(JA) IKK2阻害に基づく優れた抗炎症作用を有する、ピリジン環に含窒素飽和へテロ環基又は置換アミノ基が置換し、チオフェン環上にカルボキサミド基とアミノ基を有することを特徴とする三環系化合物、及び同三環系化合物を用いた、炎症性疾患又は自己免疫疾患等の治療又は予防薬の提供。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)