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1. (WO2005123684) ENANTIOSELEKTIVE PREPARATION OF QUINOLINE DERIVATIVE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/123684    International Application No.:    PCT/EP2005/006686
Publication Date: 29.12.2005 International Filing Date: 21.06.2005
IPC:
C07D 215/26 (2006.01), C07D 251/26 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35, CH-4056 Basel (CH) (AE, AG, AL, AM, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
NOVARTIS PHARMA GMBH [AT/AT]; Brunner Strasse 59, A-1230 Vienna (AT) (AT only).
LOHSE, Olivier [FR/FR]; (CH) (For US Only).
VOGEL, Caspar [CH/CH]; (CH) (For US Only).
PENN, Gerhard [AT/CH]; (CH) (For US Only)
Inventors: LOHSE, Olivier; (CH).
VOGEL, Caspar; (CH).
PENN, Gerhard; (CH)
Agent: MOLAC, Beatrice; Novartis AG, Corporate Intellectual Property, CH-4002 Basel (CH)
Priority Data:
0413960.6 22.06.2004 GB
Title (EN) ENANTIOSELEKTIVE PREPARATION OF QUINOLINE DERIVATIVE
(FR) COMPOSÉS ORGANIQUES
Abstract: front page image
(EN)A process for preparing 8-substituted oxy-5-((R)-2-halo-l-hydroxy-ethyl)-(1 H)-quinolin-2-ones or acceptable solvates thereof. The process involves reacting a 5-(&agr;-haloacetyl)-8-substituted oxy-(1H)-quinolin-2-one with a reducing agent in the presence of a chiral agent and a base to form a 8-(substituted oxy)-5-((R)-2-halo-l-hydroxy-ethyl)-(1H)-quinolin-2-one, said chiral agent having a formula (I) or (II), wherein M, L, X, R1, R2 and R3 have the meanings as indicated in the specification.
(FR)La présente invention concerne un procédé permettant de préparer des oxy-5-((R)-2-halo-l-hydroxy-éthyl)-(1H)-quinolin-2-ones substitués à la position 8 ou des solvates acceptables de ceux-ci. Le procédé susmentionné consiste à faire réagir un 5-($g(a)-haloacétyl)-8-substitué oxy-(1H)-quinolin-2-one avec un agent réducteur en présence d'un agent chiral et d'une base afin de former un 8-(substitué oxy)-5-((R)-2-halo-l-hydroxy-éthyl)-(1H)-quinolin-2-one; lequel agent chiral étant représenté par la formule (I) ou par la formule (II), dans ces formules, M, L, X, R1, R2 et R3 sont tels que définis dans la description.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)