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1. (WO2005123144) SYSTEM AND METHOD FOR AN AUTOMATED SYNTHESIS OF GALLIUM-68 GENERATOR-BASED RADIOPHARMACEUTICAL AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/123144    International Application No.:    PCT/US2005/002063
Publication Date: 29.12.2005 International Filing Date: 19.01.2005
IPC:
A61K 51/00 (2006.01), A61M 36/14 (2006.01)
Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 210 West 7th St., Austin, TX 78701 (US) (For All Designated States Except US).
CHAO, K., S., Clifford [US/US]; (US) (For US Only).
YANG, David, J. [US/US]; (US) (For US Only).
MOURTADA, Firas [US/US]; (US) (For US Only)
Inventors: CHAO, K., S., Clifford; (US).
YANG, David, J.; (US).
MOURTADA, Firas; (US)
Agent: BAHLER, David, D.; Fulbright & Jaworski, LLP, 600 Congress Avenue, Suite 2400, Austin, TX 78701 (US)
Priority Data:
60/538,191 20.01.2004 US
Title (EN) SYSTEM AND METHOD FOR AN AUTOMATED SYNTHESIS OF GALLIUM-68 GENERATOR-BASED RADIOPHARMACEUTICAL AGENTS
(FR) SYSTEME ET PROCEDE DE SYNTHESE AUTOMATIQUE D'AGENTS RADIOPHARMACEUTIQUES BASES SUR LE GENERATEUR DE GALLIUM-68
Abstract: front page image
(EN)Systems and methods are described for efficiently producing a radiopharmaceutical agent. The system includes a generator that provides an admixture comprising hydrochloric acid and gallium-68 (Ga-68). A heater initiates a removal process by evaporating the hydrochloric acid from the admixture resulting in a substantially purified Ga-68. A plurality of valves provides a buffer and a prodrug that gets mixed with the Ga-68 to produce Ga-68 radiopharmaceutical agent.. Additionally, the valves may provide water or a transchelator to the Ga-68 radiopharmaceutical agent to optimize the yield. A method includes providing an admixture comprising hydrochloric acid and Ga-68. The method also includes removing the hydrochloric acid by heating the admixture and subsequently evaporating the hydrochloric acid, resulting in a substantially purified Ga-68. The method further includes adding a buffer and a prodrug to the substantially purified Ga-68 to produce the Ga-68 radiopharmaceutical agent.
(FR)L'invention concerne des systèmes et des procédés permettant la production efficace d'un agent radiopharmaceutique. Le système comprend un générateur qui fournit un mélange contenant un acide hydrochloridrique et un gallium-68 (Ga-68). Un chauffage initie un processus de séparation par l'évaporation de l'acide hydrochloridrique du mélange, ce qui permet d'obtenir du Ga-68 sensiblement purifié. Une pluralité de valves délivre un tampon et un prodrogue qui est mélangé au Ga-68 pour donner un agent radiopharmaceutique Ga-68. De plus, les valves peuvent délivrer de l'eau ou un transchélateur à l'agent radiopharmaceutique Ga-68 pour optimiser le rendement. Un procédé comporte la délivrance d'un mélange contenant un acide hydrochlorhydrique et du Ga-68. Le procédé comporte également la séparation de l'acide hydrochloridrique par le chauffage du mélange puis l'évaporation consécutive de l'acide hydrochlorhydrique, ce qui permet d'obtenir un Ga-68 sensiblement purifié. Le procédé comporte également l'addition d'un tampon et d'un prodrogue au Ga-68 sensiblement purifié pour obtenir l'agent radiopharmaceutique Ga-68.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)