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1. (WO2005123140) PREPARATION OF MACROMOLECULAR CONJUGATES BY FOUR-COMPONENT CONDENSATION REACTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/123140    International Application No.:    PCT/US2005/020138
Publication Date: 29.12.2005 International Filing Date: 08.06.2005
IPC:
A61K 47/48 (2006.01)
Applicants: ALZA CORPORATION [US/US]; 1900 Charleston Road, Mountain View, CA 94043 (US) (For All Designated States Except US).
ZALIPSKY, Samuel [US/US]; (US) (For US Only)
Inventors: ZALIPSKY, Samuel; (US)
Agent: GORTHEY, Leeann; Perkins Coie LLP, P.O. Box 2168, Menlo Park, CA 94026 (US)
Priority Data:
60/578,199 08.06.2004 US
Title (EN) PREPARATION OF MACROMOLECULAR CONJUGATES BY FOUR-COMPONENT CONDENSATION REACTION
(FR) PREPARATION DE CONJUGUES MACROMOLECULAIRES PAR REACTION DE CONDENSATION A QUATRE COMPOSANTS
Abstract: front page image
(EN)Polymer-biomolecule conjugates are prepared, generally in a site-specific or -selective manner, by a four-component condensation reaction. The method may be used to prepare conjugates having two polymer molecules attached at a single site on a biomolecule. The conjugates are typically water soluble and have beneficial pharmacological properties, such as reduced immunogenicity and increased circulation time.
(FR)L'invention concerne la préparation de conjugués biomoléculaires polymères, d'ordinaire d'une manière spécifique ou sélective du site, par réaction de condensation à quatre composants. On peut utiliser ce procédé pour préparer des conjugués ayant deux molécules polymères fixées à un site simple sur une biomolécule. Les conjugués sont d'ordinaire hydrosolubles et présentent des propriétés pharmacologiques intéressantes, par exemple une immunogénicité réduite et un temps de circulation accru.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)