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1. (WO2005123124) Q FEVER VACCINE PREPARATION AND METHOD OF PRODUCING THE VACCINE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/123124 International Application No.: PCT/JP2005/011319
Publication Date: 29.12.2005 International Filing Date: 21.06.2005
IPC:
A61K 39/02 (2006.01) ,A61K 39/00 (2006.01) ,A61P 31/04 (2006.01) ,C12N 1/20 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
20
Bacteria; Culture media therefor
Applicants: KOMIYA, Tomoyoshi[JP/JP]; JP (UsOnly)
ARAI, Setsuo[JP/JP]; JP (UsOnly)
HIRAI, Katsuya[JP/JP]; JP (UsOnly)
FUKUSHI, Hideto[JP/JP]; JP (UsOnly)
YAMAGUCHI, Tsuyoshi[JP/JP]; JP (UsOnly)
THE KITASATO INSTITUTE[JP/JP]; 9-1, Shirokane 5-chome Minato-ku, Tokyo 1088642, JP (AllExceptUS)
Inventors: KOMIYA, Tomoyoshi; JP
ARAI, Setsuo; JP
HIRAI, Katsuya; JP
FUKUSHI, Hideto; JP
YAMAGUCHI, Tsuyoshi; JP
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Bldg. 6F 1-1-1, Oroshi-machi, Tsuchiura-shi, Ibaraki 3000847, JP
Priority Data:
2004-18425922.06.2004JP
Title (EN) Q FEVER VACCINE PREPARATION AND METHOD OF PRODUCING THE VACCINE
(FR) PRÉPARATION D'UN VACCIN CONTRE LA FIÈVRE Q ET PROCÉDÉ DE PRODUCTION DU VACCIN
(JA) Q熱のワクチン製剤および該ワクチン製剤の製造方法
Abstract:
(EN) It is found out for the first time that a bacterium coxiella can be cultured by the serum-free culture method. Thus, it is clarified that a vaccine can be produced by the serum-free culture method with the use of the bacterial cells thus obtained. A Q fever vaccine preparation, which contains an antigen obtained by culturing the above-described coxiella under serum-free conditions as the active ingredient, has a significant characteristic of being free from any unknown pathological contaminant and is highly advantageous in the fields of medicine and pharmacology, compared with the vaccines produced by the conventional methods.
(FR) On a trouvé pour la première fois qu'on peut mettre en culture une bactérie coxiella par le procédé de culture sans sérum. Ainsi, il est expliqué qu'on peut produire un vaccin par le procédé de culture sans sérum grâce à l'utilisation des cellules bactériennes ainsi obtenues. Une préparation de vaccin contre la fièvre Q, laquelle contient comme ingrédient actif un antigène obtenu en mettant en culture la coxiella décrite ci-dessus dans des conditions sans sérum, a une caractéristique importante consistant en ce qu'elle est exempte de tout contaminant pathologique inconnu et qu'elle est extrêmement avantageuse dans les domaines de la médecine et de la pharmacologie, par rapport aux vaccins produits par les procédés classiques.
(JA)  本発明者らは、無血清培養法でコクシエラ菌の培養が可能であることを初めて見出し、この菌体を用いることにより、無血清培養法によるワクチン製造が可能であることを明らかにした。本発明のコクシエラ菌を無血清培養することで得られる抗原を有効成分として含有するQ熱ワクチン製剤は、従来製造されてきたワクチンと比較し、未知の病原因子が混入していないという有意な特性を持っており、医療・製薬分野で非常に有益なものである。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)