WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2005123115) METHODS OF MODULATING CELLULAR ACTIVITY INVOLVING SPHINGOSINE KINASE AND AGENTS FOR SAME, AND SPHINGOSINE KINASE VARIANTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/123115    International Application No.:    PCT/AU2005/000856
Publication Date: 29.12.2005 International Filing Date: 15.06.2005
IPC:
A61K 38/43 (2006.01), A61K 38/18 (2006.01), A61K 38/19 (2006.01), A61K 38/00 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01), C12N 9/12 (2006.01)
Applicants: MEDVET SCIENCE PTY. LTD. [AU/AU]; 38 Payneham Road, Stepney, South Australia 5069 (AU) (For All Designated States Except US).
PITSON, Stuart, M. [AU/AU]; (AU) (For US Only).
VADAS, Mathew, Alexander [AU/AU]; (AU) (For US Only).
XIA, Pu [AU/AU]; (AU) (For US Only).
MORETTI, Paul, A. [AU/AU]; (AU) (For US Only).
LECLERCQ, Tamara [AU/AU]; (AU) (For US Only).
SUTHERLAND, Catherine [AU/AU]; (AU) (For US Only)
Inventors: PITSON, Stuart, M.; (AU).
VADAS, Mathew, Alexander; (AU).
XIA, Pu; (AU).
MORETTI, Paul, A.; (AU).
LECLERCQ, Tamara; (AU).
SUTHERLAND, Catherine; (AU)
Agent: OBRANOVICH, Tania, D; DAVIES COLLISON CAVE, 1 Nicholson Street, Melbourne, Victoria 3000 (AU)
Priority Data:
2004903249 15.06.2004 AU
Title (EN) METHODS OF MODULATING CELLULAR ACTIVITY INVOLVING SPHINGOSINE KINASE AND AGENTS FOR SAME, AND SPHINGOSINE KINASE VARIANTS
(FR) PROCEDE DE MODULATION DE L'ACTIVITE CELLULAIRE FAISANT INTERVENIR UNE SPHINGOSINE KINASE, AGENTS UTILISES A CET EFFET ET VARIANTES DE SPHINGOSINE KINASE
Abstract: front page image
(EN)The present invention relates generally to a method of modulating cellular activity and to agents for use therein. More particularly, the present invention provides a method of modulating cellular activity by modulating intracellular translocation of sphingosine kinase to the cell membrane. In a related aspect, the present invention provides a method of modulating sphingosine kinase mediated signalling via modulation of its intracellular translocation and agents for use therein. The present invention still further extends to sphingosine kinase variants and to functional derivatives, homologues and analogues thereof, exhibiting ablated or reduced capacity to undergo translocation. The method and molecules of the present invention are useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate cellular functional activity and/or aberrant, unwanted or otherwise inappropriate sphingosine kinase mediated signalling. The present invention is further directed to methods for identifying and/or designing agents capable of modulating sphingosine kinase intracellular translocation.
(FR)Procédé de modulation de l'activité cellulaire et agents utilisés à cet effet. Plus particulièrement, procédé de modulation de l'activité cellulaire par modulation de la translocation intracellulaire de la sphingosine kinase vers la membrane cellulaire. Selon une variante, on prévoit un procédé de modulation de la signalisation induite par la sphingosine kinase via la modulation de sa translocation intracellulaire et des agents utilisés à cet effet. Variantes de la sphingosine kinase et dérivés fonctionnels, homologues et analogues faisant preuve d'une capacité amputée ou réduite pour effectuer une translocation. Le procédé et les molécules de cette invention sont utilisés, entre autres, dans le traitement et/ou la prévention de conditions caractérisées par une activité fonctionnelle cellulaire aberrante, indésirable ou inappropriée et/ou une signalisation induite par la sphingosine kinase aberrante, indésirable ou inappropriée. Procédé d'identification et/ou de conception d'agents aptes à moduler la translocation intracellulaire de la sphingosine kinase.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)