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1. (WO2005123089) MULTICYCLIC SULFONAMIDE COMPOUNDS AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/123089    International Application No.:    PCT/US2005/020769
Publication Date: 29.12.2005 International Filing Date: 09.06.2005
IPC:
A61K 31/16 (2006.01), A61K 31/34 (2006.01), A61K 31/40 (2006.01), A61K 31/44 (2006.01), C07D 317/44 (2006.01), C07D 453/02 (2006.01), C07D 209/04 (2006.01), C07C 303/00 (2006.01)
Applicants: KALYPSYS, INC. [US/US]; 10420 Wateridge Circle, San Diego, California 92121 (US) (For All Designated States Except US).
MALECHA, James [US/US]; (US).
NOBLE, Stewart [GB/US]; (US).
HASSIG, Christian [US/US]; (US).
WASH, Paul [US/US]; (US).
WILEY, Brandon [US/US]; (US).
LAWRENCE, Charles [US/US]; (US).
HOFFMAN, Timothy [US/US]; (US)
Inventors: MALECHA, James; (US).
NOBLE, Stewart; (US).
HASSIG, Christian; (US).
WASH, Paul; (US).
WILEY, Brandon; (US).
LAWRENCE, Charles; (US).
HOFFMAN, Timothy; (US)
Agent: HO, Raymond, J.; International Patent Group, P.O. Box 38129, St. Louis, MO 63138 (US)
Priority Data:
10/865,743 10.06.2004 US
PCT/US2004/018502 10.06.2004 US
60/635,020 09.12.2004 US
Title (EN) MULTICYCLIC SULFONAMIDE COMPOUNDS AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE
(FR) COMPOSES SULFONAMIDE MULTICYCLIQUES INHIBANT L'HISTONE DESACETYLASE POUR LE TRAITEMENT DE MALADIE
Abstract: front page image
(EN)Disclosed herein are carbonyl compounds of Formula (I) as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
(FR)L'invention concerne des composés carbonyle (formule I) ainsi que des procédés et des compositions pour le traitement de maladies, à savoir entre autres : cancer, maladies auto-immunes, dégâts aux tissus, troubles du système nerveux central, maladies neurodégénératives, fibrose, troubles osseux, troubles de répétition de polyglutamine, anémie, thalassémie, maladies inflammatoires, maladies cardio-vasculaires et troubles dans lesquels l'angiogenèse joue un rôle pour la pathogenèse. Ces procédés et compositions reposent sur l'utilisation des composés considérés. On décrit enfin des procédés de modulation de l'activité de l'histone désacétylase.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)