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Pub. No.:    WO/2005/121341    International Application No.:    PCT/CA2005/000899
Publication Date: 22.12.2005 International Filing Date: 10.06.2005
C12N 15/13 (2006.01), C07K 16/30 (2006.01), G01N 33/574 (2006.01), A61K 39/395 (2006.01), A61P 35/00 (2006.01), A61K 47/48 (2006.01), A61K 38/17 (2006.01), C12N 15/12 (2006.01), C07K 14/05 (2006.01)
Applicants: VIVENTIA BIOTECH INC. [CA/CA]; 5060 Spectrum Way, Suite 405, Mississauga, Ontario L4W 5N5 (CA) (For All Designated States Except US).
GLOVER, Nicholas, Ronald [CA/CA]; (CA) (For US Only).
MACDONALD, Glen, Christopher [CA/CA]; (CA) (For US Only).
ENTWISTLE, Joycelyn [CA/CA]; (CA) (For US Only).
CIZEAU, Jeannick [FR/CA]; (CA) (For US Only).
BOSC, Denis, Georges [CA/CA]; (CA) (For US Only).
CHAHAL, Francina, C. [IN/CA]; (CA) (For US Only)
Inventors: GLOVER, Nicholas, Ronald; (CA).
MACDONALD, Glen, Christopher; (CA).
ENTWISTLE, Joycelyn; (CA).
CIZEAU, Jeannick; (CA).
BOSC, Denis, Georges; (CA).
CHAHAL, Francina, C.; (CA)
Agent: BERESKIN & PARR; 40 King Street, Suite 4000, Toronto, Ontario M5H 3Y2 (CA)
Priority Data:
60/578,291 10.06.2004 US
Abstract: front page image
(EN)The present invention provides the amino acid and nucleic acid sequences of heavy chain and light chain complementarity determining regions of a tumor specific antibody. In addition, the invention provides tumor-specific antibodies and immunoconjugates comprising the tumor-specific antibody attached to a toxin or label, and methods and uses thereof. The invention also relates to diagnostic methods and kits using the tumor-specific antibodies of the invention.
(FR)La prEsente invention concerne les sEquences d'acides aminEs et d'acides nuclEiques de rEgions dEterminant la complEmentaritE de chaInes lourdes et de chaInes lEgEres d'un anticorps spEcifique d'une tumeur. En plus, l'invention concerne des anticorps spEcifiques d'une tumeur et des immunoconjuguEs comprenant l'anticorps spEcifique d'une tumeur attachE A une toxine ou A un marqueur et des procEdEs d'utilisation de ceux-ci. L'invention concerne Egalement des procEdEs et kits de diagnostic utilisant les anticorps spEcifiques d'une tumeur décrits ci-dessus.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)