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1. (WO2005121174) NOVEL G-CSF POLYPEPTIDES, POLYNUCLEOTIDES, MODULATORS THEREOF, AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/121174 International Application No.: PCT/US2005/019491
Publication Date: 22.12.2005 International Filing Date: 03.06.2005
IPC:
C07K 14/535 (2006.01) ,C07K 16/24 (2006.01) ,C12N 15/27 (2006.01) ,A61K 38/19 (2006.01) ,C12N 1/21 (2006.01) ,C12N 5/10 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
53
Colony-stimulating factor (CSF)
535
Granulocyte CSF; Granulocyte-macrophage CSF
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
24
against cytokines, lymphokines or interferons
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
12
Genes encoding animal proteins
19
Interferons; Lymphokines; Cytokines
27
Colony stimulating factors
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
19
Cytokines; Lymphokines; Interferons
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
20
Bacteria; Culture media therefor
21
modified by introduction of foreign genetic material
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
Applicants: LINNEMANN, Thomas[DE/US]; US (UsOnly)
CHU, Keting[US/US]; US (UsOnly)
HESTIR, Kevin[US/US]; US (UsOnly)
LIN, Haishan[US/US]; US (UsOnly)
WILLIAMS, Lewis, T.[US/US]; US (UsOnly)
LEE, Ernestine[US/US]; US (UsOnly)
FIVE PRIME THERAPEUTICS, INC.[US/US]; 951 Gateway Boulevard South San Francisco, CA 94080, US (AllExceptUS)
Inventors: LINNEMANN, Thomas; US
CHU, Keting; US
HESTIR, Kevin; US
LIN, Haishan; US
WILLIAMS, Lewis, T.; US
LEE, Ernestine; US
Agent: GARRETT, Arthur, S.; Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P. 901 New York Avenue, NW Washington, DC 20001-4413, US
Priority Data:
60/577,31604.06.2004US
Title (EN) NOVEL G-CSF POLYPEPTIDES, POLYNUCLEOTIDES, MODULATORS THEREOF, AND METHODS OF USE
(FR) NOUVEAUX POLYPEPTIDES G-CSF, POLYNUCLEOTIDES, MODULATEURS ASSOCIES ET LEURS METHODES D'UTILISATION
Abstract:
(EN) Disclosed herein are two newly identified G-CSF splice variant molecules, their polypeptide sequences, the polynucleotides encoding the polypeptide sequences, and active fragments thereof. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells. Also disclosed are methods for utilizing such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.
(FR) L'invention concerne deux molécules à variants d'épissage G-CSF nouvellement identifiées, leurs séquences de polypeptides, les polynucléotides codant lesdites séquences, et des fragments actifs associés. Cette invention a aussi pour objet une procédure destinée à produire de tels polypeptides au moyen de techniques de recombinaison utilisant, par exemple, des vecteurs et des cellules hôtes. Ladite invention a aussi trait à des méthodes d'utilisation de tels polypeptides et modulateurs dans le traitement de maladies, notamment, de cancer, de maladies immunes, de maladies infectieuses, et de maladies ischémiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)