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Pub. No.: WO/2005/121107 International Application No.: PCT/EP2005/005896
Publication Date: 22.12.2005 International Filing Date: 01.06.2005
Chapter 2 Demand Filed: 08.12.2005
C07D 239/70 (2006.01) ,A61K 31/4162 (2006.01)
Applicants: DING, Qingjie[US/US]; US (UsOnly)
JIANG, Nan[US/US]; US (UsOnly)
ROBERTS, John, Lawson[US/US]; US (UsOnly)
F. HOFFMANN-LA ROCHE AG[CH/CH]; Grenzacherstrasse 124 CH-4070 Basel, CH (AllExceptUS)
Inventors: DING, Qingjie; US
ROBERTS, John, Lawson; US
Agent: KLEIN, Thomas; Grenzacherstrasse 124 CH-4070 Basel, CH
Priority Data:
Abstract: front page image
(EN) Novel pyrazolopyrimidines of formula (I), are discussed. These pyrazolopyrimidines are capable of inhibiting the activity of cyclin-dependent kinases, most particularly cyclin-dependent kinase 1 (Cdk1), cyclin-dependent kinase 2 (Cdk2), and cyclin-dependent kinase 4 (Cdk4) and are thus useful, inter alga, in the treatment or control of cancer, in particular solid tumors. This invention also provides pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors.
(FR) L'invention concerne de nouveaux pyrazolopyrimidines de formule (I). Ces pyrazolopyrimidines peuvent inhiber l'activité de kinases dépendant de la cycline, notamment, de la kinase 1 dépendant de la cycline (Cdk1), de la kinase 2 dépendant de la cycline (Cdk2) et de la kinase 4 dépendant de la cycline (Cdk4), et ils sont ainsi utilisés, inter alia, dans le traitement ou le contrôle d'un cancer, notamment, de tumeurs solides. Ladite invention a aussi trait à des compositions pharmaceutiques contenant de tels composés et à des méthodes de traitement ou de contrôle, plus spécifiquement, de traitement ou de contrôle de tumeurs du sein, des poumons, du côlon et de la prostate.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)