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1. (WO2005121094) PIPERAZINE AND PIPERIDINE DERIVATIVES AS ANTI-HIV-AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/121094    International Application No.:    PCT/IB2005/001677
Publication Date: 22.12.2005 International Filing Date: 30.05.2005
IPC:
C07D 217/22 (2006.01), C07D 213/74 (2006.01), C07D 471/04 (2006.01), C07D 487/04 (2006.01), C07D 413/12 (2006.01), C07D 491/04 (2006.01), C07D 401/12 (2006.01), A61K 31/496 (2006.01), A61P 31/18 (2006.01)
Applicants: PFIZER LIMITED [GB/GB]; Ramsgate Road, Sandwich, Kent CT13 9NJ (GB) (GB only).
FENWICK, David, Roy [GB/GB]; (GB) (For US Only).
MIDDLETON, Donald, Stuart [GB/GB]; (GB) (For US Only).
STEPHENSON, Peter, Thomas [GB/GB]; (GB) (For US Only).
TRAN, Thien-Duc [FR/GB]; (GB) (For US Only).
WILLIAMS, David, Howard [GB/GB]; (GB) (For US Only).
PFIZER INC. [US/US]; 235 East 42nd Street, New York, NY 10017 (US) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only)
Inventors: FENWICK, David, Roy; (GB).
MIDDLETON, Donald, Stuart; (GB).
STEPHENSON, Peter, Thomas; (GB).
TRAN, Thien-Duc; (GB).
WILLIAMS, David, Howard; (GB)
Agent: RUDDOCK, Keith, S.; Pfizer Research and Development, Ramsgate Road, Sandwcih, Kent CT13 9NJ (GB)
Priority Data:
0412877.3 09.06.2004 GB
60/588,653 16.07.2004 US
Title (EN) PIPERAZINE AND PIPERIDINE DERIVATIVES AS ANTI-HIV-AGENTS
(FR) DERIVES DE PIPERAZINE ET DE PIPERIDINE UTILISES COMME AGENTS ANTI-VIH
Abstract: front page image
(EN)This invention relates to a compound of formula (I) or pharmaceutically acceptable salts, solvates or derivatives thereof, wherein R1 to R5 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation, compositions containing them and the uses of such derivatives. The compounds of the present invention inhibit the interaction of gp120 with CD4 and are 10 therefore of use in the treatment of HIV, a retroviral infection genetically related to HIV, or AIDS.
(FR)L'invention concerne un composé représenté par la formule (I) ou des sels, des solvates et des dérivés acceptables d'un point de vue pharmaceutique de celui-ci, formule dans laquelle R1 à R5 sont tels que définis dans la description. L'invention concerne également des méthodes de préparation desdits composés, des intermédiaires utilisés dans leur préparation, des compositions les contenant, et les utilisations de tels dérivés. Les composés de la présente invention inhibent l'interaction de gp120 avec CD4 et sont, par conséquent, utilisés dans le traitement du VIH, d'une infection rétrovirale associée au VIH, ou du SIDA.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)