WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2005121071) PROCESS FOR THE PREPARATION OF NATEGLINIDE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/121071    International Application No.:    PCT/GB2005/002267
Publication Date: 22.12.2005 International Filing Date: 08.06.2005
Chapter 2 Demand Filed:    10.04.2006    
IPC:
C07C 231/02 (2006.01), C07C 233/63 (2006.01), A61K 31/165 (2006.01), A61P 3/10 (2006.01)
Applicants: CIPLA LIMITED [IN/IN]; 289 Bellasis Road, Mumbai central, Mumbai 400 008 (IN) (For All Designated States Except US).
KANKAN, Rajendra, Narayanrao [IN/IN]; (IN) (For US Only).
RAO, Dharmaraj, Ramachandra [IN/IN]; (IN) (For US Only).
SINGH, Manjinder [IN/IN]; (IN) (For US Only).
BIRARI, Dilip, Ramdas [IN/IN]; (IN) (For US Only).
WAIN, Christopher, Paul [GB/GB]; (GB) (MW only)
Inventors: KANKAN, Rajendra, Narayanrao; (IN).
RAO, Dharmaraj, Ramachandra; (IN).
SINGH, Manjinder; (IN).
BIRARI, Dilip, Ramdas; (IN)
Agent: CURTIS, Philip, Anthony; A.A. Thornton & Co., 235 High Holborn, London WC1V 7LE (GB)
Priority Data:
0413084.5 11.06.2004 GB
Title (EN) PROCESS FOR THE PREPARATION OF NATEGLINIDE
(FR) PROCEDE DE FABRICATION DE NATEGLINIDE
Abstract: front page image
(EN)One-pot process for the preparation of nateglinide, which process comprises reacting an alkyl ester of D-phenylalanine of formula (II) where R represents C1-4 alkyl, typically methyl, either as the free base or in salt form (typically the hydrochloride), with trans-4-isopropylcyclohexanecarboxylic acid of formula (III) where X represents hydroxy or halo, typically chloro, to obtain a C1-4 alkyl ester of nateglinide of formula (IV), preferably the methyl ester of nateglinide followed by hydrolysis to yield nateglinide of formula (I).
(FR)L'invention concerne un procédé monotope de fabrication de natéglinide consistant à faire réagir un alkylester de D-phénylalanine de la formule (II), dans laquelle R est C1-4-alkyl, notamment méthyl, soit sous forme de base libre, soit sous forme de sel (notamment de chlorhydrate), avec de l'acide trans-4-isopropylcyclohexane-carboxylique de la formule (III), dans laquelle X est hydroxy ou halo, notamment chloro, de manière à obtenir un C1-4-alkylester de natéglinide de la formule (IV), de préférence le méthylester de natéglinide, puis à réaliser une hydrolyse de manière à obtenir le natéglinide de la formule (I).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)