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Machine translation
1. (WO2005121066) THE PREPARATION METHOD OF (1 R,2S)-(-)-EPHEDRINE OR ITS HYDROCHLORIDE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/121066    International Application No.:    PCT/CN2005/000743
Publication Date: 22.12.2005 International Filing Date: 27.05.2005
Chapter 2 Demand Filed:    30.12.2005    
IPC:
C07C 215/30 (2006.01), C07C 213/00 (2006.01), C07M 7/00
Applicants: SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY [CN/CN]; 1320, Beijing Road (W), Shanghai 200040 (CN) (For All Designated States Except US).
ZHEJIANG KANGYU PHARMACEUTICAL CO., LTD. [CN/CN]; 8, Jiangnan West Road, Hengdian Village, Dongyang, Zhejiang 322118 (CN) (For All Designated States Except US).
HUANG, Chengjun [CN/CN]; (CN) (For US Only).
ZHOU, Houyuan [CN/CN]; (CN) (For US Only)
Inventors: HUANG, Chengjun; (CN).
ZHOU, Houyuan; (CN)
Agent: CHINA SINDA INTELLECTUAL PROPERTY LTD.; B11th Floor, Focus Place, 19 Financial Street, Beijing 100032 (CN)
Priority Data:
200410024953.8 07.06.2004 CN
Title (EN) THE PREPARATION METHOD OF (1 R,2S)-(-)-EPHEDRINE OR ITS HYDROCHLORIDE
(FR) PROCEDE DE PREPARATION DE (1R, 2S)-(X)-EPHEDRINE OU D'UN HYDROCHLORURE DE CETTE DERNIERE
Abstract: front page image
(EN)IN this invention, (1 R,2S)-(-)-ephedrine is obtained by reacting, [(S)-(-)-&agr;-methylaminophenylacetone]2 . (2R,3R)-tartaric acid derivatives or the salts of (S)-(-)-&agr;-methylaminophenylacetone and other organic acids with metal borohydride or the mixture consisting of metal borohydride and lewis acid. Since the staring materials don't racemize during the reductive reaction, the ephedrine should be predominant in the product. In addition, the utilization of the metal borohydride is high.
(FR)L'invention permet d'obtenir de la (1R, 2S)-(-)-éphédrine en faisant réagir des dérivés de l'acide [(S)-(-)-$g(a)-méthylaminophénylacétone]2 ? (2R, 3R)-tartrique ou les sels de la (S)-(-)-$g(a)-méthylaminophénylacétone et d'autres acides organiques avec un borohydrure métallique ou un mélange composé d'un borohydrure métallique et d'un acide de Lewis. Etant donné que les matières de départ ne se racémisent pas durant la période de réduction, l'éphédrine est prédominante dans le produit. En outre, il est fait une utilisation importante du borohydrure métallique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)