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1. (WO2005120583) METHOD FOR PREVENTING OR TREATING CARDIAC HYPERTROPHY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/120583    International Application No.:    PCT/US2005/020873
Publication Date: 22.12.2005 International Filing Date: 14.06.2005
IPC:
C07H 21/00 (2006.01), A61K 48/00 (2006.01)
Applicants: WISCONSIN ALUMNI RESEARCH FOUNDATION [US/US]; 614 Walnut Street, 13th Floor, Madison, WI 53726 (US) (For All Designated States Except US).
SMITH, Susan, M. [US/US]; (US) (For US Only).
LOUGH, John, W., Jr. [US/US]; (US) (For US Only).
FLENTKE, George, R. [US/US]; (US) (For US Only)
Inventors: SMITH, Susan, M.; (US).
LOUGH, John, W., Jr.; (US).
FLENTKE, George, R.; (US)
Agent: LI, Kening; CROWELL & MORING LLP, Intellectual Property Group, P.O. Box 14300, Washington, DC 20044-4300 (US)
Priority Data:
60/578,877 14.06.2004 US
Title (EN) METHOD FOR PREVENTING OR TREATING CARDIAC HYPERTROPHY
(FR) METHODE PERMETTANT DE PREVENIR OU DE TRAITER L'HYPERTROPHIE CARDIAQUE
Abstract: front page image
(EN)A method for treating or preventing cardiac hypertrophy in a mammal, comprising manipulating levels of RBP, retinoids, or an affiliated signaling and regulatory pathway in the mammal. Preferably, the method comprises reducing or inhibiting the level of RBP or retinoids or their signaling pathway, or an affiliated signaling pathway, via a dietary, genetic, protein-based, or pharmacologic approach, or a combination thereof. Also disclosed are pharmaceutical composition suitable for the method.
(FR)L'invention concerne une méthode permettant de traiter ou de prévenir l'hypertrophie cardiaque chez un mammifère et consistant à manipuler des taux de RBP, des rétinoïdes ou une signalisation affiliée et la voie de régulation chez le mammifère. De préférence, la méthode consiste à réduire ou à inhiber le taux de RBP ou de rétinoïdes ou leur voie de signalisation au moyen d'une approche diététique, génétique, à base de protéines ou pharmacologique ou d'une combinaison de ces dernières. L'invention concerne également une composition pharmaceutique appropriée à cette méthode.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)