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1. (WO2005120570) THERAPEUTIC TARGETING OF PARC/CCL18 AND ITS SIGNALING IN PULMONARY FIBROSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/120570 International Application No.: PCT/US2005/019461
Publication Date: 22.12.2005 International Filing Date: 03.06.2005
IPC:
C07H 21/04 (2006.01) ,A61K 48/00 (2006.01)
Applicants: ATAMAS, Sergei[US/US]; US (UsOnly)
LUZINA, Irina[UA/US]; US (UsOnly)
WHITE, Barbara[US/US]; US (UsOnly)
THE UNIVERSITY OF MARYLAND, BALTIMORE[US/US]; 520 West Lombard Street Baltimore, Maryland 21201, US (AllExceptUS)
Inventors: ATAMAS, Sergei; US
LUZINA, Irina; US
WHITE, Barbara; US
Agent: BUCK, Todd; Castellano Malm Ferrarrio & Buck PLLC 2121 K Street, NW Suite 800 Washington, DC 20037, US
Priority Data:
60/576,44203.06.2004US
Title (EN) THERAPEUTIC TARGETING OF PARC/CCL18 AND ITS SIGNALING IN PULMONARY FIBROSIS
(FR) CIBLAGE THERAPEUTIQUE DE PARC/CCL18 ET SA SIGNALISATION DANS LA FIBROSE PULMONAIRE
Abstract: front page image
(EN) The present invention relates to methods of treating, preventing or preventing the progression of fibrosis comprising inhibiting the actions of pulmonary and activation-regulated chemokine (PARC) or at least one of its downstream effector molecules, such as Sp1 transcription factor and protein kinase C-alpha (PKC&agr;). The present invention also relates to methods of screening and/or identifying compounds useful for the treatment of fibrosis comprising contacting PARC or its downstream effector molecules, such as Sp1 or PKC&agr;, with a substance and subsequently determining the effects of the substance on the activity of PARC or Sp1 or PKC&agr;. The present invention also relates to methods of screening and/or identifying compounds that prevent or inhibit collagen deposition comprising contacting PARC or its downstream effector molecules, such as Sp1 or PKC&agr;, with a substance and subsequently determining the effects of the substance on the activity of PARC or Sp1 or PKC&agr;.
(FR) La présente invention concerne des méthodes destinées à traiter ou prévenir la fibrose ou empêcher son évolution. Ces méthodes consistent à inhiber les effets de la chimiokine pulmonaire régulée par activation (PARC) ou d'au moins une de ses molécules effectrices en aval, telles que le facteur de transcription Sp1 et la protéine kinase C-alpha (PKC$g(a)). L'invention concerne également des méthodes de criblage et/ou d'identification de composés utiles pour le traitement de la fibrose, qui consistent à placer PARC ou ses molécules effectrices en aval, telles que Sp1 ou PKC$g(a), au contact d'une substance; puis à déterminer les effets de la substance sur l'activité de PARC ou de Sp1 ou de PKC$g(a). L'invention concerne en outre des méthodes de criblage et/ou d'identification de composés pouvant empêcher ou inhiber le dépôt de collagène, qui consistent à placer PARC ou ses molécules effectrices en aval, telles que Sp1 ou PKC$g(a), au contact d'une substance; puis à déterminer les effets de la substance sur l'activité de PARC ou de Sp1 ou de PKC$g(a).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)