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1. (WO2005120505) TETRAHYDROPYRANYL CYCLOPENTYL TETRAHY-DROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/120505    International Application No.:    PCT/US2005/013754
Publication Date: 22.12.2005 International Filing Date: 22.04.2005
IPC:
C07D 213/02 (2006.01), C07D 217/00 (2006.01), A61K 31/44 (2006.01), A61K 31/47 (2006.01), A61K 31/4375 (2006.01)
Applicants: MERCK & CO., INC [US/US]; 126 East Lincoln Avenue, Rahway, NJ 07065-0907 (US) (For All Designated States Except US).
YANG, Lihu [US/US]; (US) (For US Only).
MILLS, Sander, G. [US/US]; (US) (For US Only).
JIAO, Richard [US/US]; (US) (For US Only)
Inventors: YANG, Lihu; (US).
MILLS, Sander, G.; (US).
JIAO, Richard; (US)
Common
Representative:
MERCK & CO., INC; David A. Rubin, 126 East Lincoln Avenue, Rahway, NJ 07065-0907 (US)
Priority Data:
60/565,380 26.04.2004 US
Title (EN) TETRAHYDROPYRANYL CYCLOPENTYL TETRAHY-DROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
(FR) TETRAHYDROPYRANYL CYCLOPENTYL TETRAHY-DROPYRIDOPYRIDINE MODULANT L'ACTIVITE DES RECEPTEURS DE LA CHIMIOKINE
Abstract: front page image
(EN)Compounds of Formula I (wherein n, R1, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, Y and Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.
(FR)L'invention concerne des composés de formule I (n, R1, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, Y et Z tels que définis dans la description) qui modulent l'activité des récepteurs de la chimiokine et sont utiles dans la prévention ou le traitement d'un certain nombre de troubles et de maladies inflammatoires et immunorégulateurs/trices, de maladies allergiques, d'états atopiques comme la rhinite, la dermatite, la conjonctivite et l'asthme, y compris les pathologies auto-immunes du type arthrite rhumatoïde et athérosclérose. L'invention concerne enfin des compositions pharmaceutiques renfermant les composés en question et l'utilisation de ces composés et compositions dans la prévention ou le traitement de telles maladies, qui font intervenir les récepteurs de la chimiokine.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)