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1. (WO2005120435) METHOD FOR PREPARING SUSTAINED RELEASE COMPOSITIONS AND THE USE OF SAID COMPOSITIONS FOR TREATING CHRONIC DISEASES OF CENTRAL NERVOUS SYSTEM (CNS)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/120435    International Application No.:    PCT/FR2005/001128
Publication Date: 22.12.2005 International Filing Date: 04.05.2005
IPC:
A61K 9/08 (2006.01), A61K 9/16 (2006.01), A61K 9/00 (2006.01)
Applicants: ETHYPHARM [FR/FR]; 21, rue Saint-Mathieu, F-78550 Houdan (FR) (For All Designated States Except US).
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) [FR/FR]; 101, rue de Tolbiac, F-75013 Paris (FR) (For All Designated States Except US).
LAGARCE, Frédéric [FR/FR]; (FR) (For US Only).
RICHARD, Joël [FR/FR]; (FR) (For US Only).
BENOIT, Jean-Pierre [FR/FR]; (FR) (For US Only).
FAISANT, Nathalie [FR/FR]; (FR) (For US Only).
MENEI, Philippe [FR/FR]; (FR) (For US Only)
Inventors: LAGARCE, Frédéric; (FR).
RICHARD, Joël; (FR).
BENOIT, Jean-Pierre; (FR).
FAISANT, Nathalie; (FR).
MENEI, Philippe; (FR)
Agent: MARTIN, Jean-Jacques; Cabinet Regimbeau, 20, rue de Chazelles, F-75847 Paris Cedex 17 (FR)
Priority Data:
0404814 05.05.2004 FR
Title (EN) METHOD FOR PREPARING SUSTAINED RELEASE COMPOSITIONS AND THE USE OF SAID COMPOSITIONS FOR TREATING CHRONIC DISEASES OF CENTRAL NERVOUS SYSTEM (CNS)
(FR) PROCEDE DE PREPARATION DE COMPOSITIONS A LIBERATION PROLONGEE ET UTILISATION DE CES COMPOSITIONS POUR LE TRAITEMENT DES AFFECTIONS CHRONIQUES DU SYSTEME NERVEUX CENTRAL (SNC)
Abstract: front page image
(EN)The inventive method for preparing microspheres comprising poly (D,L-lactide-co-glycolide), poly(D,L-lactide (PLAGA or PLA)) or the mixtures thereof which are ethyl acetate soluble and encapsulate at least one type of ethyl acetate non-soluble active substance. Compositions containing microspheres homogeneously dispersed in a biocompatible polymer solution capable to form a gel in situ after administration through a haemo-meningeal barrier (HMB) for treating CNS chronic diseases are also disclosed.
(FR)Procédé de préparation de microsphères comprenant du poly(D,L-lactide-co-glycolide), du poly(D,L-lactide (PLAGA ou PLA)) ou leurs mélanges, solubles dans l’acétate d’éthyle, encapsulant au moins une substance active insoluble dans l’acétate d’éthyle. Compositions comprenant les microsphères dispersées de façon homogène dans une solution de polymère(s) biocompatible(s) capable(s) de former un gel in situ, après administration à travers la barrière hémo-méningée (BHM), pour le traitement des affections chroniques du SNC. La substance active préférée est la bacloféne.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: French (FR)
Filing Language: French (FR)