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Machine translation
1. (WO2005118840) DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH KALLIKREIN 10 (KLK10)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/118840    International Application No.:    PCT/EP2005/005782
Publication Date: 15.12.2005 International Filing Date: 30.05.2005
IPC:
C12Q 1/37 (2006.01), G01N 33/68 (2006.01), A61K 38/00 (2006.01), A61K 39/00 (2006.01), A61K 48/00 (2006.01)
Applicants: BAYER HEALTHCARE AG [DE/DE]; 51368 Leverkusen (DE) (For All Designated States Except US).
GOLZ, Stefan [DE/DE]; (DE) (For US Only).
BRÜGGEMEIER, Ulf [DE/DE]; (DE) (For US Only).
GEERTS, Andreas [DE/DE]; (DE) (For US Only).
SUMMER, Holger [DE/DE]; (DE) (For US Only)
Inventors: GOLZ, Stefan; (DE).
BRÜGGEMEIER, Ulf; (DE).
GEERTS, Andreas; (DE).
SUMMER, Holger; (DE)
Common
Representative:
BAYER HEALTHCARE AG; Law and Patents, Patents and Licensing, 51368 Leverkusen (DE)
Priority Data:
04013108.8 03.06.2004 EP
Title (EN) DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH KALLIKREIN 10 (KLK10)
(FR) ELEMENTS DIAGNOSTIQUES THERAPEUTIQUES POUR DES MALADIES ASSOCIEES A LA KALLIKREINE 10 (KLK10)
Abstract: front page image
(EN)The invention provides a human KLK10 which is associated with the endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, muscle-skeleton disorders, cardiovascular disorders, neurological disorders, urological disorders, respiratory diseases and reproduction disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, muscle-skeleton disorders, cardiovascular disorders, neurological disorders, urological disorders, respiratory diseases and reproduction disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of KLK10 as well as pharmaceutical compositions comprising such compounds.
(FR)La présente invention concerne une KLK10 humaine associée à des troubles du système endocrinien et à des troubles hormonaux, des pathologies cancéreuses, des maladies du métabolisme, des maladies du tube digestif et du foie, des troubles musculo-squelettiques, des troubles cardio-vasculaires, des troubles neurologiques, des troubles urologiques, des maladies respiratoires et des troubles de la reproduction. Cette invention concerne aussi des dosages destinés à identifier des composés qui conviennent pour le traitement ou la prévention de troubles du système endocrinien et des troubles hormonaux, des pathologies cancéreuses, des maladies du métabolisme des maladies du tube digestif et du foie, des troubles musculo-squelettiques, des troubles cardio-vasculaires, des troubles neurologiques que, des troubles urologiques, des maladies respiratoires et des troubles de la reproduction. C'est invention concerne aussi des composés qui se lient et/ou qui activent ou inhibent l'activité de KLK10 ainsi que des compositions pharmaceutiques comprenant ces composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)