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1. (WO2005118808) NUCLEIC ACID MOLECULES AS HEPARANASE POTENT INHIBITORS, COMPOSITIONS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/118808    International Application No.:    PCT/IL2005/000570
Publication Date: 15.12.2005 International Filing Date: 01.06.2005
IPC:
C12N 15/11 (2006.01), C12N 9/24 (2006.01)
Applicants: HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD. [IL/IL]; P.O. Box 12000, 91120 Jerusalem (IL) (For All Designated States Except US).
VLODAVSKY, Israel [IL/IL]; (IL) (For US Only).
EDOVITSKY, Evgeny [IL/IL]; (IL) (For US Only).
ELKIN, Michael [IL/IL]; (IL) (For US Only).
ZCHARIA, Eyal [IL/IL]; (IL) (For US Only).
PERETZ, Tamar [IL/IL]; (IL) (For US Only)
Inventors: VLODAVSKY, Israel; (IL).
EDOVITSKY, Evgeny; (IL).
ELKIN, Michael; (IL).
ZCHARIA, Eyal; (IL).
PERETZ, Tamar; (IL)
Agent: LUZZATTO, Kfir; P.O. Box 5352, 84152 Beer Sheva (IL)
Priority Data:
162276 01.06.2004 IL
Title (EN) NUCLEIC ACID MOLECULES AS HEPARANASE POTENT INHIBITORS, COMPOSITIONS AND METHODS OF USE THEREOF
(FR) MOLECULES D'ACIDE NUCLEIQUE SERVANT D'INHIBITEURS PUISSANTS D'HEPARANASE, LEURS COMPOSITIONS ET LEURS METHODES D'UTILISATION
Abstract: front page image
(EN)Disclosed herein are ribonucleic acid molecules, specifically ribozymes and siRNAs, whose sequence is at least partially complementary to heparanase mRNA. Said molecules may thus be used for the specific inhibition of heparanase, and as therapeutics for pathologic conditions associated with heparanase expression, like for example tumor formation, progression and metastasis, tumor-associated angiogenesis, inflammatory disorders, kidney disorders and autoimmune disorders. Vectors, cells and compositions comprising said ribonucleic acid molecules are also disclosed herein.
(FR)L'invention concerne des molécules d'acide ribonucléique, en particulier des ribozymes et des ARNic dont la séquence est au moins partiellement complémentaire à un ARNm d'héparanase. Ces molécules peuvent être utilisées pour l'inhibition spécifique de l'héparanase, et en tant que substances thérapeutiques pour des troubles pathologiques associés à l'expression de l'héparanase, comme par exemple, la formation et la croissance de tumeurs, les métastases, l'angiogenèse associée à une tumeur, les troubles inflammatoires, les troubles rénaux et les troubles auto-immuns. L'invention concerne également des vecteurs, des cellules et des compositions comprenant de telles molécules d'acide ribonucléique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)