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Machine translation
1. (WO2005118796) RECONSTITUTED HISTONE METHYLTRANSFERASE COMPLEX AND METHODS OF IDENTIFYING MODULATORS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/118796    International Application No.:    PCT/US2005/018840
Publication Date: 15.12.2005 International Filing Date: 27.05.2005
Chapter 2 Demand Filed:    01.06.2006    
IPC:
C12N 9/10 (2006.01), C12N 5/10 (2006.01)
Applicants: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL [US/US]; 308 Bynum Hall, Campus Box 4105, Chapel Hill, NC 27599-4105 (US) (For All Designated States Except US).
ZHANG, Yi [US/US]; (US) (For US Only).
CAO, Ru [US/US]; (US) (For US Only)
Inventors: ZHANG, Yi; (US).
CAO, Ru; (US)
Agent: MYERS BIGEL SIBLEY & SAJOVEC, P.A.; P.O. Box 37428, Raleigh, NC 27627 (US)
Priority Data:
60/575,880 01.06.2004 US
Title (EN) RECONSTITUTED HISTONE METHYLTRANSFERASE COMPLEX AND METHODS OF IDENTIFYING MODULATORS THEREOF
(FR) COMPLEXE D'HISTONE METHYLTRANSFERASE RECONSTITUE ET METHODES ASSOCIEES D'IDENTIFICATION DE MODULATEURS
Abstract: front page image
(EN)The present invention provides a reconstituted complex including EED, EZH2 and SUZ12 wherein the reconstituted complex has histone methyltransferase (HMTase) activity for lysine 27 of histone H3 (H3-K27). The reconstituted complex may further include RbAp48, AEBP2 or both. Also disclosed are methods of producing the reconstituted complex, methods of identifying compounds that inhibit the HTMase activity of the reconstituted complex and methods of identifying candidate compounds for treating cancer. Reagents and kits including the reconstituted complex are further provided.
(FR)La présente invention concerne un complexe reconstitué contenant EED, EZH2 et SUZ12 et présentant une activité d'histone méthyltransférase (HMTase) pour la lysine 27 d'histone H3 (H3-K27). Ledit complexe reconstitué peut aussi comprendre RbAp48, AEBP2 ou les deux à la fois. Cette invention a aussi pour objet des méthodes de production du complexe reconstitué, des méthodes d'identification de composés qui inhibent l'activité HTMase du complexe reconstitué et des méthodes d'identification de composés candidats pour le traitement d'un cancer. Ladite invention a également trait à des réactifs et à des kits contenant le complexe reconstitué.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)