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Machine translation
1. (WO2005118643) ANTIBODIES TO ANGIOGENESIS INHIBITING DOMAINS OF CD148
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/118643    International Application No.:    PCT/US2005/013939
Publication Date: 15.12.2005 International Filing Date: 21.04.2005
IPC:
C07K 16/28 (2006.01), A61K 39/395 (2006.01), A61P 35/00 (2006.01), A61P 37/00 (2006.01), C12N 15/13 (2006.01), C12N 15/63 (2006.01), C12N 5/10 (2006.01)
Applicants: AMGEN INC. [US/US]; Law Department, One Amgen Center Drive, Thousand Oaks, CA 91320-1799 (US) (For All Designated States Except US).
SMOTHERS, James, F. [US/US]; (US) (For US Only).
FANSLOW, William, C., III [US/US]; (US) (For US Only).
KARIV, Revital [IL/US]; (US) (For US Only)
Inventors: SMOTHERS, James, F.; (US).
FANSLOW, William, C., III; (US).
KARIV, Revital; (US)
Agent: RAN, David, B.; Angen Inc., 1201 Amgen Court West, Seattle, Washington 98119-3105 (US)
Priority Data:
60/564,885 23.04.2004 US
60/585,686 06.07.2004 US
Title (EN) ANTIBODIES TO ANGIOGENESIS INHIBITING DOMAINS OF CD148
(FR) ANTICORPS DE L'ANGIOGENÈSE INHIBANT DES DOMAINES DE CD148
Abstract: front page image
(EN)The present invention provides compositions and methods relating to anti-CD148 receptor antibodies. Methods provided include inhibiting angiogenesis and, thereby, vascularization of solid tumors in human patients. The present invention also provides compositions and methods for in vivo imaging of tumors expressing CD148. Compositions of the invention include: anti-CD148 antibodies, antigen binding regions of anti-CD148 antibodies, polynucleotides encoding anti-CD148 antibodies or binding regions thereof, vectors comprising these polynucleotides, host cells, and pharmaceutical compositions. Methods of making and using each of these compositions is also provided.
(FR)La présente invention concerne des compositions et des procédés liés à des anticorps de récepteurs anti-CD148. Les procédés selon l'invention consistent à inhiber l'angiogenèse et donc la vascularisation de tumeurs solides chez des patients humains. La présente invention concerne également des compositions et des procédés d'imagerie in vivo de tumeurs exprimant CD148. Les compositions selon l'invention contiennent des anticorps anti-CD148, des régions de liaison d'antigènes d'anticorps anti-CD148, des polynucléotides codant des anticorps anti-CD148 ou des régions de liaison de ceux-ci, des vecteurs contenant ces polynucléotides, des cellules hôtes, et des compositions pharmaceutiques. L'invention concerne également des procédés de fabrication et d'utilisation desdites compositions.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)