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1. (WO2005118640) A H+-GATED ION CHANNEL
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/118640    International Application No.:    PCT/US2005/013415
Publication Date: 15.12.2005 International Filing Date: 20.04.2005
C07K 14/00 (2006.01), C12N 15/11 (2006.01), G01N 33/53 (2006.01)
Applicants: UNIVERSITY OF UTAH RESEARCH FOUNDATION [US/US]; c/o Technology Transfer Office, Suite 310, 615 Arapeen Drive, Salt Lake City, UT 84108 (US) (For All Designated States Except US).
JORGENSEN, Erik, M. [US/US]; (US) (For US Only).
BEG, Asim, A. [US/US]; (US) (For US Only).
DAL SANTO, Paola [US/US]; (US) (For US Only)
Inventors: JORGENSEN, Erik, M.; (US).
BEG, Asim, A.; (US).
DAL SANTO, Paola; (US)
Agent: TURNER, Allen, C.; P.O. Box 2550, Salt Lake City, UT 84110 (US)
Priority Data:
60/563,939 20.04.2004 US
Abstract: front page image
(EN)The invention relates to an isolated or recombinant Na+/H+ exchanger comprising an isolated or recombinant Na+/H+ exchanger, particularly to the PBO-4 Na+/H+ exchanger. In addition, isolated or recombinant protein component of an H+-gated channel which may be is effected by extracellular Ca2+ concentration. In particular, the invention relates to PBO-5 and/or PBO-8 and/or a H+-gated channel composed of PBO-5 and PBO-8. The invention relates to compounds isolated from a vertebrate organism, wherein said compounds comprise at least a part of a a H+-gated channel or Na+/H+ exchanger. The invention also relates to a method for identifying a component of a H+-gated channel in a vertebrate organism.
(FR)L'invention concerne un échangeur Na+/H+ isolé ou recombiné comprenant un échangeur Na+/H+ isolé ou recombiné, notamment l'échangeur Na+/H+ PBO-4. Par ailleurs, un composant protéique recombiné ou isolé d'un canal ouvert par H+, qui peut être obtenu par concentration de Ca2+ extracellulaire, est décrit. L'invention se rapporte en particulier à PBO-5 et/ou à PBO-8 et/ou à un canal ionique ouvert par H+, constitué de PBO-5 et de PBO-8. Elle se rapporte encore à des composés isolés dans un organisme vertébré, composés comprenant au moins une partie d'un canal ouvert par H+ ou d'un échangeur Na+/H+. Elle concerne également une méthode d'identification d'un composant d'un canal ouvert par H+ dans un organisme vertébré.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)