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1. (WO2005118635) ANTI-CD3 ANTIBODIES AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2005/118635 International Application No.: PCT/US2005/019922
Publication Date: 15.12.2005 International Filing Date: 03.06.2005
IPC:
C07K 16/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
Applicants:
NOVIMMUNE S.A. [CH/CH]; 64, Avenue de la Roseraie CH-1211, Geneva, CH (AllExceptUS)
MACH, Bernard [CH/CH]; CH (UsOnly)
DEAN, Yann [FR/FR]; FR (UsOnly)
KOSCO-VILBOIS, Marie [US/FR]; FR (UsOnly)
ELSON, Greg, Christopher, Andrew [GB/FR]; FR (UsOnly)
FISCHER, Nicolas [CH/CH]; CH (UsOnly)
LEGER, Olivier [FR/FR]; FR (UsOnly)
Inventors:
MACH, Bernard; CH
DEAN, Yann; FR
KOSCO-VILBOIS, Marie; FR
ELSON, Greg, Christopher, Andrew; FR
FISCHER, Nicolas; CH
LEGER, Olivier; FR
Agent:
ELRIFI, Ivor, R.; Mintz, Levin, Cohn, Ferris, Glovsky, and Popeo PC One Financial Center Boston, MA 02111, US
Priority Data:
60/576,48303.06.2004US
60/609,15310.09.2004US
Title (EN) ANTI-CD3 ANTIBODIES AND METHODS OF USE THEREOF
(FR) ANTICORPS ANTI-CD3 ET LEURS METHODES D'UTILISATION
Abstract:
(EN) The present invention is related to antibodies directed to the antigen CD3 and uses of such antibodies. In particular, the present invention provides fully human monoclonal antibodies directed to CD3. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR’s), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
(FR) La présente invention concerne des anticorps dirigés contre l'antigène CD3 et leurs utilisations. Notamment, cette invention a trait à des anticorps monoclonaux entièrement humains dirigés contre CD3. Ladite invention a également pour objet le codage de séquences de nucléotides et des séquences d'acides aminés contenant des molécules d'immunoglobines à chaînes lourde et légère, plus spécifiquement, des séquences correspondant à des séquences à chaînes lourde et légère contigües qui étalent les régions de structure et/ou les régions de détermination de la complémentarité (CDR's), particulièrement de FR1 par FR4 ou de CDR1 par CDR3. L'invention concerne aussi des hybridomes ou d'autres lignées cellulaires exprimant de telles molécules d'immunoglobines et des anticorps monoclonaux.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO20066052MXPA/a/2006/014075KR1020070038495ZA2006/09891IL179672EP1753783
JP2008503449CN1984931CA2569509EA200602276ES2526343AU2005250499
DK1753783IN3743/KOLNP/2006