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1. (WO2005118634) HELICAL PEPTIDOMIMETICS WITH ENHANCED ACTIVITY AGAINST BETA-AMYLOID PRODUCTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/118634    International Application No.:    PCT/US2005/019809
Publication Date: 15.12.2005 International Filing Date: 03.06.2005
IPC:
C07K 14/81 (2006.01), C07K 14/47 (2006.01), A61K 38/57 (2006.01), A61K 38/17 (2006.01), A61P 25/28 (2006.01)
Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC. [US/US]; 75 Francis Street, Boston, MA 02115 (US) (For All Designated States Except US).
WOLFE, Michael, S. [US/US]; (US) (For US Only)
Inventors: WOLFE, Michael, S.; (US)
Agent: STEELE, Alan, W.; Wolf, Greenfield & Sacks, P.C., 600 Atlantic Avenue, Boston, MA 02210 (US)
Priority Data:
60/576,965 04.06.2004 US
Title (EN) HELICAL PEPTIDOMIMETICS WITH ENHANCED ACTIVITY AGAINST BETA-AMYLOID PRODUCTION
(FR) COMPOSES PEPTIDOMIMETIQUES HELICOIDAUX A ACTIVITE AMELIOREE
Abstract: front page image
(EN)Helical peptidomimetic compounds as inhibitors of beta-amyloid production are provided. These inhibitors have sequences with lengths from 11 to 16 amino acids, inclusive. These inhibitors potently inhibit intramembrane proteases, notably aspartyl secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid-&bgr;-peptide. Methods are provided for making a medicament containing the compounds and for administering the compounds to treat &bgr;-amyloid-associated diseases, notably Alzheimer's disease.
(FR)L'invention concerne des composés peptidomimétiques hélicoïdaux utilisés en tant qu'inhibiteurs de la production d'amyloïdes béta. Lesdits inhibiteurs comportent des séquences présentant des longueurs comprises entre 11 et 16 aminoacides. Lesdits inhibiteurs inhibent potentiellement des protéases intermembranaires, notamment des sécrétases d'aspartyle impliquées dans le clivage enzymatique de la protéine précurseur amyloïde (APP) pour produire un peptide amyloïde $g(b). L'invention concerne des procédés pour fabriquer un médicament contenant lesdits composés et pour administrer les composés destinés à traiter les maladies associées à l'amyloïde $g(b), notamment la maladie d'Alzheimer.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)