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Pub. No.:    WO/2005/118554    International Application No.:    PCT/US2005/019394
Publication Date: 15.12.2005 International Filing Date: 02.06.2005
C07D 235/18 (2006.01), C07F 5/02 (2006.01)
Applicants: PHARMACYCLICS, INC. [US/US]; 995 E. Arques Avenue, Sunnyvale, CA 94085 (US) (For All Designated States Except US).
DICKMAN, Daniel, A. [US/US]; (US) (For US Only).
KUMAR, Dange Vijay [IN/US]; (US) (For US Only).
O'BRYAN, Colin [US/US]; (US) (For US Only).
RAI, Roopa [US/US]; (US) (For US Only).
SHRADER, William, Dvorak [US/US]; (US) (For US Only).
WESSON, Kieron [US/US]; (US) (For US Only)
Inventors: DICKMAN, Daniel, A.; (US).
KUMAR, Dange Vijay; (US).
O'BRYAN, Colin; (US).
RAI, Roopa; (US).
SHRADER, William, Dvorak; (US).
WESSON, Kieron; (US)
Agent: KEZER, William, B.; Townsend and Townsend and Crew LLP, Two Embarcadero Center, 8th Floor, San Francisco, CA 94111 (US)
Priority Data:
60/576,382 02.06.2004 US
Abstract: front page image
(EN)The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
(FR)L'invention concerne de nouveaux inhibiteurs des facteurs VIIa, IXa, Xa, XIa, en particulier du facteur VIIa, des compositions pharmaceutiques contenant ces inhibiteurs, et des méthodes pour utiliser ces inhibiteurs dans le traitement ou la prévention de troubles thromboemboliques, du cancer ou de la polyarthrite rhumatoïde. La présente invention porte également sur des procédés pour préparer ces inhibiteurs.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)