WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2005118522) MONOMETHYLPHYTOSPHINGOSINE- POLYETHYLENEGLY COL AND THE COMPOSITION FOR ANTI-CANCER CONTAINING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/118522    International Application No.:    PCT/KR2005/001438
Publication Date: 15.12.2005 International Filing Date: 17.05.2005
IPC:
C07C 215/10 (2006.01)
Applicants: DOOSAN CORPORATION [KR/KR]; 18-12, 6th St., Ulchi-ro, Chung-gu, Seoul 100-730 (KR) (For All Designated States Except US).
LIM, Dae-Seog [KR/KR]; (KR) (For US Only).
KIM, Jinwook [KR/KR]; (KR) (For US Only).
PARK, Sungjin [KR/KR]; (KR) (For US Only).
HWANG, You-A [KR/KR]; (KR) (For US Only).
PARK, Changseo [KR/KR]; (KR) (For US Only).
LEE, Ho-Jae [KR/KR]; (KR) (For US Only)
Inventors: LIM, Dae-Seog; (KR).
KIM, Jinwook; (KR).
PARK, Sungjin; (KR).
HWANG, You-A; (KR).
PARK, Changseo; (KR).
LEE, Ho-Jae; (KR)
Agent: KIM, Sun-young; Korea Coal Center, 10th Floor, 80-6, Susong-Dong, Chongro-Ku, Seoul 110-727 (KR)
Priority Data:
10-2004-0039704 01.06.2004 KR
Title (EN) MONOMETHYLPHYTOSPHINGOSINE- POLYETHYLENEGLY COL AND THE COMPOSITION FOR ANTI-CANCER CONTAINING THE SAME
(FR) MONOMETHYLPHYTOSPHINGOSINE- POLYETHYLENEGLY COL ET COMPOSITION ANTI-CANCEREUSE CONTENANT LEDIT COMPOSE
Abstract: front page image
(EN)Disclosed are a monomethylphytosphingosine-polyethyleneglycol (MMPS-PEG) derivative formed by combining monomethylphytosphingosine (MMPS), which is a derivative of sphingolipid, with polyethyleneglycol (PEG) or a pharmaceutically acceptable salt thereof and a composition containing the same. The compound inhibits a growth of tumor xenografted to the mammal, thereby treating or preventing a cancer or a cancer-related disease. In addition, it is possible to inhibit an activity of promoting a cell proliferation, thereby treating or preventing a hyper-proliferative disease such as a cancer and psoriasis. Further, a solubility of the monomethylphytosphingosine is improved and a toxicity thereof influencing on the human body is reduced, thereby remarkably expanding the application ranges thereof.
(FR)L'invention concerne un dérivé de monométhylphytosphingosine-polyéthylèneglycol (MMPS-PEG) formé par combinaison de monométhylphytosphingosine (MMPS), qui est un dérivé d'un sphingolipide, et de polyéthylèneglycol (PEG) ou d'un sel acceptable d'un point de vue pharmaceutique de celui-ci, et une composition contenant ledit dérivé. Ledit composé inhibe la croissance d'une tumeur xénogreffée chez un mammifère, afin de traiter ou de prévenir un cancer ou une maladie associée à un cancer. Ledit composé peut également inhiber une activité favorisant la prolifération cellulaire, afin de traiter ou de prévenir une maladie hyperproliférative telle que le cancer ou le psoriasis. La solubilité de la monométhylphytosphingosine est, de plus, améliorée et sa toxicité sur le corps humain est réduite, son champ d'application étant ainsi significativement étendu.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: Korean (KO)