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1. (WO2005117991) COMPOSITIONS AND METHODS FOR ENHANCING DELIVERY OF NUCLEIC ACIDS INTO CELLS AND FOR MODIFYING EXPRESSION OF TARGET GENES IN CELLS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2005/117991 International Application No.: PCT/US2005/015574
Publication Date: 15.12.2005 International Filing Date: 04.05.2005
IPC:
C12N 15/87 (2006.01) ,C12N 15/11 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
87
Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
Applicants:
NASTECH PHARMACEUTICAL COMPANY INC. [US/US]; 3450 Monte Villa Parkway Bothell, WA 98021-8906, US (AllExceptUS)
CHEN, Lishan [US/--]; US (UsOnly)
CUI, Kunyuan [US/US]; US (UsOnly)
CHEN, Yuching [--/US]; US (UsOnly)
MAYER, Sasha, J. [CA/US]; US (UsOnly)
Inventors:
CHEN, Lishan; US
CUI, Kunyuan; US
CHEN, Yuching; US
MAYER, Sasha, J.; US
Agent:
KNUDSEN, Peter, J. ; Nastech Pharmaceutical Company Inc. 3450 Monte Villa Parkway Bothell, WA 98021-8909, US
Priority Data:
60/568,02704.05.2004US
60/570,51212.05.2004US
60/570,51312.05.2004US
60/613,41627.09.2004US
60/656,57225.02.2005US
60/667,83301.04.2005US
Title (EN) COMPOSITIONS AND METHODS FOR ENHANCING DELIVERY OF NUCLEIC ACIDS INTO CELLS AND FOR MODIFYING EXPRESSION OF TARGET GENES IN CELLS
(FR) COMPOSITIONS ET PROCEDES POUR L'AMELIORATION DE L'ADMINISTRATION D'ACIDES NUCLEIQUES DANS DES CELLULES ET POUR LA MODIFICATION DE L'EXPRESSION DE GENES CIBLES DANS DES CELLULES
Abstract:
(EN) Polynucleotide delivery-enhancing polypeptides are admixed or complexed with, or conjugated to, nucleic acids for enhancing delivery the nucleic acids into cells. The transported nucleic acids are active in target cells as small inhibitory nucleic acids (siNAs) that modulate expression of target genes, mediated at least in part by RNA interference (RNAi). The siNA/polypeptide compositions and methods of the invention provide effective tools to modulate gene expression and alter phenotype in mammalian cells, including by altering phenotype in a manner that eliminates disease symptoms or alters disease potential in targeted cells or subject individuals to which the siNA/polypeptide compositions are administered.
(FR) La présente invention a trait à des polypeptides assurant une amélioration de polynucléotides additionnés ou complexés avec, ou conjugués à, des acides nucléiques pour l'amélioration de l'administration d'acides nucléiques dans des cellules. Les acides nucléiques transportés sont actifs dans des cellules cibles en tant que petits acides nucléiques inhibiteurs qui réalisent la modulation de l'expression des gènes cibles, par l'intermédiaire au moins partiellement d'ARN interférence (ARNi). Les compositions à base de petits acides nucléiques inhibiteurs /polypeptides et les procédés de l'invention fournissent des outils efficaces pour la modulation de l'expression générique et la modification de phénotype dans des cellules mammaliennes, y compris la modification de phénotype d'une manière permettant l'élimination de symptômes de maladies et de modification de potentiel de maladies dans des cellules cibles ou chez des sujets individuels auxquels les compositions à base de petits acides nucléiques inhibiteurs/polypeptides sont administrés
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)