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Machine translation
1. (WO2005117906) COMBINATION FOR INHIBITING BONE RESORPTION COMPRISING A BISPHOSPONATE (ALENDRONA) AND A VITAMIN D (CHOLECALCIFEROL)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/117906    International Application No.:    PCT/US2004/015743
Publication Date: 15.12.2005 International Filing Date: 19.05.2004
Chapter 2 Demand Filed:    13.12.2005    
IPC:
A61K 31/663 (2006.01), A61K 31/69 (2006.01), A61P 19/02 (2006.01), A61P 19/08 (2006.01), A61P 19/10 (2006.01), G01N 33/82 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, NJ 07065 (US) (For All Designated States Except US).
DAIFOTIS, Anastasia, G. [US/US]; (US) (For US Only).
DENKER, Andrew [US/US]; (US) (For US Only).
IKEDA, Craig [US/US]; (US) (For US Only).
MATUSZEWSKI, Bogdan, K. [US/US]; (US) (For US Only).
MAZEL, Sid [US/US]; (US) (For US Only).
PORRAS, Arturo, G. [US/US]; (US) (For US Only).
SANTORA, Art [US/US]; (US) (For US Only).
SEBURG, Randal, Alan [US/US]; (US) (For US Only).
ZHU, Limin [US/US]; (US) (For US Only).
YATES, John [US/US]; (US) (For US Only).
KIRSCH, John, D. [US/US]; (US) (For US Only)
Inventors: DAIFOTIS, Anastasia, G.; (US).
DENKER, Andrew; (US).
IKEDA, Craig; (US).
MATUSZEWSKI, Bogdan, K.; (US).
MAZEL, Sid; (US).
PORRAS, Arturo, G.; (US).
SANTORA, Art; (US).
SEBURG, Randal, Alan; (US).
ZHU, Limin; (US).
YATES, John; (US).
KIRSCH, John, D.; (US)
Agent: BERMAN, Paul, J.; Covington & Burling, 1201 Pennsylvania Avenue, N.W., Washington, DC 20004-2401 (US).
WU, Melody, H.; Covington & Burling, 1201 Pennsylvania Avenue, N.W., Washington, DC 20004-2401 (US)
Priority Data:
Title (EN) COMBINATION FOR INHIBITING BONE RESORPTION COMPRISING A BISPHOSPONATE (ALENDRONA) AND A VITAMIN D (CHOLECALCIFEROL)
(FR) COMBINAISON POUR INHIBER LA RESORPTION OSSEUSE COMPRENANT UN BISPHOSPONATE (ALENDRONATE) ET UNE VITAMINE D (CHOLECALCIFEROL)
Abstract: front page image
(EN)Disclosed are compositions and methods for preventing, inhibiting, reducing and treating conditions and diseases associated with abnormal bone resorption in mammals, including for example osteoporosis. Embodiments of compositions of the invention comprise a pharmaceutically effective amount of alendronate and vitamin D3 suitable for once-weekly dosing. Compositions and methods of the invention provide vitamin D nutrition during bisphosphonate treatment to facilitate normal bone formation and mineralization while minimizing the occurrence of or potential for the complications associated with vitamin D insufficiency, such as hypocalcaemia and osteomalacia. Also disclosed are methods for manufacturing compositions of the present invention, for measuring stability and degradation of those compositions, and for measuring blood plasma levels of vitamin D.
(FR)L'invention concerne des compositions et des procédés pour prévenir, inhiber, réduire et traiter des états et des troubles associés à une résorption osseuse anormale chez les mammifères, y compris, par exemple, l'ostéoporose. Dans certains modes de réalisation, les compositions contiennent une quantité pharmaceutiquement efficace d'alendronate et de vitamine D3 pour un dosage hebdomadaire. Des compositions et des procédés de l'invention fournissent un apport de vitamine D durant le traitement au bisphosphonate pour promouvoir la formation et la minéralisation osseuses normales, tout en minimisant l'occurrence ou l'éventualité de complications associées à l'insuffisance en vitamine D, telle que l'hypocalcémie et l'ostéomalacie. La présente invention porte également sur des procédés pour produire les compositions de la présente invention, pour mesurer la stabilité et la dégradation de ces compositions, et pour mesurer les niveaux de plasma sanguins de la vitamine D.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)