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Pub. No.:    WO/2005/117894    International Application No.:    PCT/US2005/019591
Publication Date: 15.12.2005 International Filing Date: 03.06.2005
A61K 31/535 (2006.01), A61K 31/44 (2006.01), A61K 31/415 (2006.01), A61K 31/35 (2006.01), C07D 309/30 (2006.01), C07D 405/00 (2006.01), C07D 231/56 (2006.01), C07D 413/00 (2006.01)
Applicants: KOSAN BIOSCIENCES INCORPORATED [US/US]; 3832 Bay Center Place, Hayward, CA 94545 (US) (For All Designated States Except US).
DONG, Steven, D. [US/US]; (US) (For US Only).
SANTI, Daniel, V. [--/US]; (US) (For US Only).
MYLES, David, C. [--/US]; (US) (For US Only).
HEARN, Brian [--/US]; (US) (For US Only)
Inventors: DONG, Steven, D.; (US).
SANTI, Daniel, V.; (US).
MYLES, David, C.; (US).
HEARN, Brian; (US)
Agent: CHAO, Yuan; Kosan Biosciences, Incorporated, 3832 Bay Center Place, Hayward, CA 94545 (US)
Priority Data:
60/577,253 03.06.2004 US
60/609,981 14.09.2004 US
11/142,482 01.06.2005 US
Abstract: front page image
(EN)Leptomycin-type compounds according to formula I wherein R°, R1, R2, R10 R11 R12 R13 R14, and m are as defined herein, exhibit anti-tumor activity.
(FR)Les composés de type leptomycine selon la formule I dans laquelle R°, R1, R2, R10 R11 R12 R13 R14, et m sont tels que définis dans le présent document, présentent une activité antitumorale.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)