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Pub. No.:    WO/2005/117868    International Application No.:    PCT/US2005/018184
Publication Date: 15.12.2005 International Filing Date: 23.05.2005
A61K 31/44 (2006.01), C07D 471/04 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road, Princeton, New Jersey 08543-4000 (US) (For All Designated States Except US).
RUEDIGER, Edward, H. [CA/CA]; (CA) (For US Only).
DEON, Daniel, H. [CA/CA]; (CA) (For US Only).
KADOW, John, F. [US/US]; (US) (For US Only)
Inventors: RUEDIGER, Edward, H.; (CA).
DEON, Daniel, H.; (CA).
KADOW, John, F.; (US)
Agent: EPPERSON, James; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, New Jersey 08543-4000 (US)
Priority Data:
60/574,669 26.05.2004 US
Abstract: front page image
(EN)The invention encompasses a series of tetrahydrocarboline compounds of Formula I (I) which inhibit HIV entry by attaching to the exterior viral envelop protein gp120 and interrupting the viral entry process, possibly by interfering with the cellular receptor CD4. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
(FR)L'invention concerne une série de composés tétrahydrocarboline de la formule (I) qui inhibe l'entrée du VIH par fixation à la protéine d'enveloppe virale extérieure gp120 et par interruption du processus d'entrée virale, éventuellement par interception du récepteur cellulaire CD4. Cette action rend les composés utiles pour traiter les infections à VIH ainsi que le SIDA. L'invention concerne également des compositions pharmaceutiques et des méthodes de traitement des personnes contaminées par le VIH.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)