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Machine translation
1. (WO2005117584) IMPROVED TRANSMUCOSAL DELIVERY OF PEPTIDES AND PROTEINS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/117584    International Application No.:    PCT/US2005/001440
Publication Date: 15.12.2005 International Filing Date: 12.01.2005
IPC:
A61K 38/00 (2006.01)
Applicants: AMYLIN PHARMACEUTICALS, INC [US/US]; 9360 Towne Centre Drive, San Diego, CA 92121 (US) (For All Designated States Except US).
ONG, John [US/US]; (US) (For US Only).
JENNINGS, Robert [US/US]; (US) (For US Only).
RHODES, Christopher [US/US]; (US) (For US Only).
STETSKO, Gregg [US/US]; (US) (For US Only)
Inventors: ONG, John; (US).
JENNINGS, Robert; (US).
RHODES, Christopher; (US).
STETSKO, Gregg; (US)
Agent: MARSH, David; Arnold & Porter, 555 Twelfth Street, NW, Washington, DC 20004-1206 (US)
Priority Data:
PCT/US2004/017456 28.05.2004 US
Title (EN) IMPROVED TRANSMUCOSAL DELIVERY OF PEPTIDES AND PROTEINS
(FR) DISTRIBUTION TRANSMUCOSALE DE PEPTIDES ET DE PROTEINES AMELIOREE
Abstract: front page image
(EN)Provided are methods and compositions for enhancing the transmucosal absorption of bioactive peptides and proteins. More particularly, the invention provides compositions for enhancing the transmucosal absorption of bioactive peptides and proteins, such as exendin-4, PYY, PYY3-36, and GLP-1 and their analogs and derivatives, wherein the compositions comprise an absorption enhancing mixture of a cationic polyamino acid, at least one additional absorption enhancing agent, and a buffer that is compatible with the polyamino acid. Also provided are methods for enhancing the transmucosal absorption and bioavailability of bioactive peptides and proteins using such compositions.
(FR)L'invention concerne des méthodes et des compositions permettant d'améliorer l'absorption transmucosale de protéines et peptides bioactifs. L'invention concerne plus particulièrement des compositions permettant d'améliorer l'absorption transmucosale de protéines et peptides bioactifs, tels que l'exendine-4, PYY, PYY3-36, et GLP-1 et leurs analogues et dérivés. Lesdites compositions comprennent un mélange d'acide polyamino cationique permettant d'améliorer l'absorption, au moins un agent d'amélioration d'absorption supplémentaire et un tampon compatible avec l'acide polyamino. L'invention concerne également des méthodes permettant d'améliorer l'absorption transmucosale et la biodisponibilité des protéines et des peptides bioactifs à l'aide de ces compositions.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)