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1. (WO2005117576) MODIFICATION OF SUGAR METABOLIC PROCESS IN TRANSGENIC CELLS, TISSUES AND ANIMALS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/117576    International Application No.:    PCT/US2005/019058
Publication Date: 15.12.2005 International Filing Date: 31.05.2005
Chapter 2 Demand Filed:    28.12.2005    
IPC:
A01K 67/00 (2006.01), A01K 67/033 (2006.01), A01K 67/027 (2006.01), C12N 5/00 (2006.01), C12N 5/02 (2006.01), A01N 63/00 (2006.01)
Applicants: UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION [US/US]; Office of Technology Management, 200 Gardner Steel Conference Center, Thackeray and O'Hara Streets, Pittsburgh, PA 15260 (US) (For All Designated States Except US).
KOIKE, Chihiro [JP/US]; (US) (For US Only)
Inventors: KOIKE, Chihiro; (US)
Agent: KNOWLES, Sherry, M.; King & Spalding LLP, 191 Peachtree Street, 45th Floor, Atlanta, GA 30303-1763 (US)
Priority Data:
60/575,539 28.05.2004 US
Title (EN) MODIFICATION OF SUGAR METABOLIC PROCESS IN TRANSGENIC CELLS, TISSUES AND ANIMALS
(FR) MODIFICATION D'UN PROCESSUS DE METABOLISME DES GLUCIDES DANS DES CELLULES, DES TISSUS ET CHEZ DES ANIMAUX TRANSGENIQUES
Abstract: front page image
(EN)The present invention provides natural or transgenic galactose deficient cells, tissues, organs and animals that have been genetically modified to compensate for the abnormalities in galactose metabolic pathways. The present invention modifies sugar metabolic pathways to prevent the deleterious accumulation of sugar metabolites in animals, tissues, organs, cells and cell lines that possess natural or transgenic abnormalities in the sugar metabolic pathways. Such cells, tissues, organs and animals can be used in research and medical therapy, including xenotransplantation.
(FR)La présente invention concerne des cellules, des tissus, des organes et des animaux carents en galactose naturelle ou transgénique, qui ont été génétiquement modifiés pour compenser les anomalies des voies métaboliques de la galactose. Le procédé de l'invention modifie les voies métaboliques des glucides pour empêcher l'accumulation nuisible de métabolites des glucides chez des animaux ou dans des tissus, organes, cellules ou lignées cellulaires dont les voies métaboliques des glucides présentent des anomalies naturelles ou transgéniques. De tels cellules, tissus, organes ou animaux peuvent être utilisés dans le domaine de la recherche ou pour des traitements médicaux comme la xénotransplantation.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)