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Machine translation
1. (WO2005117538) METHODS AND COMPOSITIONS FOR INHIBITING ABAD/A&bgr; PROTEIN INTERACTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/117538    International Application No.:    PCT/US2005/012482
Publication Date: 15.12.2005 International Filing Date: 12.04.2005
IPC:
C07K 14/00 (2006.01), C07K 1/00 (2006.01), C07K 17/00 (2006.01), G01N 33/567 (2006.01), A01N 37/18 (2006.01), A61K 38/00 (2006.01)
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; West 116th Street and Broadway, New York, NY 10027 (US) (For All Designated States Except US).
CORNELL RESEARCH FOUNDATION, INC. [US/US]; 20 Thornwood Drive, Suite 105, Ithaca, NY 14850 (US) (For All Designated States Except US).
YAN, Shi, Du [US/US]; (US) (For US Only).
STERN, David, M. [US/US]; (US) (For US Only).
LUSTBADER, Joyce, W. [US/US]; (US) (For US Only).
WU, Hao [US/US]; (US) (For US Only)
Inventors: YAN, Shi, Du; (US).
STERN, David, M.; (US).
LUSTBADER, Joyce, W.; (US).
WU, Hao; (US)
Agent: WHITE, John, P.; Cooper & Dunham LLP, 1185 Avenue of the Americas, New York, NY 10036 (US)
Priority Data:
60/561,859 12.04.2004 US
Title (EN) METHODS AND COMPOSITIONS FOR INHIBITING ABAD/A&bgr; PROTEIN INTERACTION
(FR) PROCEDES ET COMPOSITIONS POUR INHIBER L'INTERACTION ENTRE L'ENZYME ABAD ET LA PROTEINE A$G(B)
Abstract: front page image
(EN)This invention provides methods, compositions and articles of manufacture for inhibiting binding between A&bgr; protein and ABAD in cells. Uses of this invention include, for example, treating Alzheimer’s disease; reducing free radical generation, DNA fragmentation, and cytochrome C release in cells; and preserving cell viability by preventing LDH release from a cell.
(FR)Cette invention concerne des procédés, des compositions et des produits destinés à inhiber la liaison entre la protéine A$g(b) et l'enzyme ABAD dans des cellules. Les utilisations de cette invention sont notamment le traitement de la maladie d'Alzheimer, la réduction de la production de radicaux libres, de la fragmentation d'ADN et de la libération des cytochromes C dans des cellules, et la préservation de la viabilité des cellules en empêchant la libération de LDH d'une cellule.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)