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Machine translation
1. (WO2005116658) METHOD FOR DETERMINING A TISSUE DEGRADATION PROCESS BY DETECTION OF COMP NEOEPITOPES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/116658    International Application No.:    PCT/EP2005/005706
Publication Date: 08.12.2005 International Filing Date: 24.05.2005
IPC:
G01N 33/68 (2006.01), C07K 14/78 (2006.01), C07K 16/18 (2006.01), C12N 15/11 (2006.01)
Applicants: ANAMAR MEDICAL AB [SE/SE]; Kungsportsavenyn 22, S-411 36 Gothenburg (SE) (For All Designated States Except US).
HEINEGÅRD, Dick [SE/SE]; (SE) (For US Only).
ÖNNERFJORD, Patrik [SE/SE]; (SE) (For US Only).
STUBENDORFF, Johann, Jakob [DE/DE]; (DE) (For US Only)
Inventors: HEINEGÅRD, Dick; (SE).
ÖNNERFJORD, Patrik; (SE).
STUBENDORFF, Johann, Jakob; (DE)
Agent: WEBBER, Philip; Frank B. Dehn & Co., St. Bride House, 10 Salisbury Square Street, London EC4Y 8JD (GB)
Priority Data:
PA 2004 00815 24.05.2004 DK
Title (EN) METHOD FOR DETERMINING A TISSUE DEGRADATION PROCESS BY DETECTION OF COMP NEOEPITOPES
(FR) METHODE DE DETERMINATION D'UN PROCESSUS DE DEGRADATION TISSULAIRE PAR DETECTION DE NEOEPITOPES COMP
Abstract: front page image
(EN)The present invention relates to a method for determining a tissue degradation process by detection on COMP (Cartilage Oligomeric Matrix Protein) neoepitopes, where said COMP neoepitopes appear after cleavage of COMP at one or more site between position 530 and 660 of the amino acid sequence of COMP. Such as between position 550 (N550) And 551 (W551) or between position 625 (N625) and 626 (P626). Furthermore, the invention relates to antibodies against COMP neoepitopes and to fragments and peptides containing COMP neoepitopes for generation of such antibodies, which fragments or peptides comprise in or more COMP neoepitopes with at least partial identity to a selected group of COMP peptides derived from the sequence between amino acids 539-550, 551-562, or 626-637 of human COMP.
(FR)La présente invention concerne une méthode de détermination d'un processus de dégradation tissulaire par détection de néoépitopes COMP (Cartilage Oligomeric Matrix Protein), lesdits néoépitopes COMP apparaissant après le clivage de la protéine COMP sur un ou plusieurs sites entre la position 530 et 660 de la séquence d'acides aminés de la protéine COMP, par exemple entre les positions 550 (N550) et 551 (W551), ou entre les positions 625 (N625) et 626 (P626). L'invention concerne, de plus, des anticorps contre les néoépitopes COMP, ainsi que des fragments ou des peptides contenant les néoépitopes COMP pour la génération desdits anticorps. Lesdits fragments ou peptides comprennent un ou plusieurs néoépitopes COMP avec une identité au moins partielle par rapport à un groupe sélectionné de peptides COMP dérivés de la séquence entre les acides aminés 539-550, 551-562, ou 626-637 de la protéine COMP humaine.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)