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1. (WO2005116226) NANOPARTICLES COMPRISING RNA LIGANDS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/116226 International Application No.: PCT/GB2005/002058
Publication Date: 08.12.2005 International Filing Date: 24.05.2005
IPC:
C12N 15/88 (2006.01) ,A61K 47/48 (2006.01) ,A61K 49/00 (2006.01) ,A61K 51/12 (2006.01) ,A61K 49/18 (2006.01) ,G01N 33/58 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
87
Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
88
using micro-encapsulation, e.g. using liposome vesicle
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
12
characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
18
characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
58
involving labelled substances
Applicants:
RADEMACHER, Thomas, William [US/GB]; GB (UsOnly)
GUMAA, Khalid, [GB/GB]; GB (UsOnly)
MARTIN-LOMAS, Manuel [ES/ES]; ES (UsOnly)
PENADES, Soledad [ES/ES]; ES (UsOnly)
OJEDA, Rafael [ES/ES]; ES (UsOnly)
BARRIENTES, Africa G. [ES/ES]; ES (UsOnly)
MIDATECH LTD [GB/GB]; 4 & 5 Dunmore Court Wootton Road Abingdon Oxford Oxfordshire OX13 6BH, GB (AllExceptUS)
Inventors:
RADEMACHER, Thomas, William; GB
GUMAA, Khalid,; GB
MARTIN-LOMAS, Manuel; ES
PENADES, Soledad; ES
OJEDA, Rafael; ES
BARRIENTES, Africa G.; ES
Agent:
KIDDLE, Simon ; Mewburn Ellis LLP York House 23 Kingsway London Greater London WC2B 6HP, GB
Priority Data:
0411537.424.05.2004GB
60/573,80524.05.2004US
Title (EN) NANOPARTICLES COMPRISING RNA LIGANDS
(FR) NANOPARTICULES COMPRENANT DES LIGANDS D'ARN
Abstract:
(EN) Broadly, the present invention relates to nanoparticles comprise having a core including metal and/or semiconductor atoms, the core being linked to RNA ligands. The RNA ligands are typically short RNA sequences designed to mimic small interfering RNA (siRNA) and micro-RNA sequences (miRNA). The nanoparticles can be used to deliver the RNA ligands and have applications in a wide range of applications, in vitro systems and for therapeutic or diagnostic applications. By way of example, the nanparticles of the present invention may be employed (1) for targeted transcriptional gene silencing, (2) for targeted mRNA degradation, (3) for imaging mRNA, (4) for inhibiting pathways by employing a plurality of RNA ligands on the same or different nanoparticles, (5) for aerosol delivery, e.g. to the lungs, (6) in combination with mRNA silencing for targeting siRNA resistant mRNA and (7) for use a tool in functional genomics.
(FR) L'invention concerne des matériaux et des procédés permettant de fabriquer des nanoparticules dont le noyau comprend des atomes métalliques et/ou semi-conducteurs, lequel noyau est lié par covalence à une pluralité de ligands, dont des ligands d'ARN. Ces ligands d'ARN peuvent inclure un petit ARN interférent ou un micro ARN. L'invention porte également sur des utilisation de ces nanoparticules à des fins thérapeutiques et diagnostiques.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)