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Machine translation
1. (WO2005116036) CURCUMOL DERIVATIVES, THE COMPOSITIONS COMPRISING THE SAME AND THE USE OF THE SAME IN THE MANUFACTURE OF MEDICAMENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/116036    International Application No.:    PCT/CN2005/000730
Publication Date: 08.12.2005 International Filing Date: 26.05.2005
IPC:
C07D 493/08 (2006.01), A61K 31/352 (2006.01), A61P 35/00 (2006.01), A61P 31/12 (2006.01)
Applicants: HANGZHOU MINSHENG PHARMACEUTICALS CO., LTD. [CN/CN]; 108 Yuhangtang Road, 310011 Hangzhou, Zhejiang (CN) (For All Designated States Except US).
WANG, Shulong [CN/CN]; (CN) (For US Only).
GUO, Dianwu [CN/CN]; (CN) (For US Only).
MENG, Zhaoke [CN/CN]; (CN) (For US Only)
Inventors: WANG, Shulong; (CN).
GUO, Dianwu; (CN).
MENG, Zhaoke; (CN)
Agent: SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC; 435 Guiping Road, 200233 Shanghai (CN)
Priority Data:
200410044336.4 26.05.2004 CN
Title (EN) CURCUMOL DERIVATIVES, THE COMPOSITIONS COMPRISING THE SAME AND THE USE OF THE SAME IN THE MANUFACTURE OF MEDICAMENT
(FR) DERIVES DE CURCUMOL, COMPOSITION EN COMPRENANT, ET LEUR UTILISATION POUR LA FABRICATION DE MEDICAMENTS
Abstract: front page image
(EN)The present invention provides curcumol derivatives of the following formula: (I) wherein: Y is selected from =CHR2, -CH2R2, =O, -OH or -OR1; R1 is selected from H, R, RCO or HO3S; said R is selected from H; saturated or unsaturated linear C1-10 hydrocarbon group, and the like; R2 is selected from F; Cl; Br; I; H; -OH; - OR; -HO3S, and the like; with the provision that R1, R2 cannot both be H; or pharmaceutical acceptable salts thereof. The present invention also provides antitumor or antiviral pharmaceutical compositions comprising said derivatives or pharmaceutical 0AA5@t0bl5 salts thereof. The present invention further provides the use of said derivatives or pharmaceutical acceptable salts in preparation of a medicament for the prophylaxis and/or treatment of tumor or an antiviral medicament.
(FR)La présente invention concerne des dérivés de curcumol représentés par la formule générale (I) suivante ou certains de ses sels pharmaceutiquement admis. Dans cette formule, Y est choisi parmi les =CHR2, -CH2R2, =O, -OH ou -OR1. R1 est choisi parmi les H, R, RCO ou HO3S. R peut être au choix H, groupe hydrocarbure linéaire en C1-C10 éventuellement saturé ou analogue. R2 peut être au choix F, Cl, Br, I, H, -OH, -OR, -HO3S et analogue. Toutefois, R1 et R2 ne peuvent pas être H tous les deux. L'invention concerne également des compositions antitumorales ou antivirales comprenant ces dérivés ou certains de leurs sels pharmaceutiquement admis. L'invention concerne enfin l'utilisation de ces dérivés ou de leurs sels pharmaceutiquement admis pour l'élaboration d'un médicament de prophylaxie et/ou de traitement de tumeurs ou de virus.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)